Protonectin (1-6): A novel chemotactic peptide from the venom of the social wasp Agelaia pallipes pallipes

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dc.contributor.authorBaptista-Saidemberg, Nicoli B. [UNESP]
dc.contributor.authorSaidemberg, Daniel M. [UNESP]
dc.contributor.authorde Souza, Bibiana M. [UNESP]
dc.contributor.authorCesar-Tognoli, Lilian M. M. [UNESP]
dc.contributor.authorFerreira, Virginia M. R.
dc.contributor.authorMendes, Maria Anita
dc.contributor.authordos Santos Cabrera, Marcia P. [UNESP]
dc.contributor.authorRuggiero Neto, Joao [UNESP]
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:55:03Z
dc.date.available2014-05-20T13:55:03Z
dc.date.issued2010-11-01
dc.description.abstractPeptides constitute the largest group of Hymenoptera venom toxins; some of them interact with GPCR, being involved with the activation of different types of leukocytes, smooth muscle contraction and neurotoxicity. Most of these toxins vary from dodecapeptides to tetradecapeptides, amidated at their C-teminal amino acid residue. The venoms of social wasps can also contains some tetra-, penta-, hexa- and hepta-peptides, but just a few of them have been structurally and functionally characterized up to now. Protonectin (ILG-TILGLLKGL-NH(2)) is a polyfunctional peptide, presenting mast cell degranulation, release of lactate dehydrogenase (LDH) from mast cells, antibiosis against Gram-positive and Gram-negative bacteria and chemotaxis for polymorphonucleated leukocytes (PMNL), while Protonectin (1-6) (ILGTIL-NH(2)) only presents chemotaxis for PMNL However, the mixture of Protonectin (1-6) with Protonectin in the molar ratio of 1:1 seems to potentiate the biological activities dependent of the membrane perturbation caused by Protonectin, as observed in the increasing of the activities of mast cell degranulation, LDH releasing from mast cells, and antibiosis. Despite both peptides are able to induce PMNL chemotaxis, the mixture of them presents a reduced activity in comparison to the individual peptides. Apparently, when mixed both peptides seems to form a supra-molecular structure, which interact with the receptors responsible for PMNL chemotaxis, disturbing their individual docking with these receptors. In addition to this, a comparison of the sequences of both peptides suggests that the sequence ILGTIL is conserved, suggesting that it must constitute a linear motif for the structural recognition by the specific receptor which induces leukocytes migration. (C) 2010 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUNESP Rio Claro, Ctr Study Social Insects CEIS, Dept Biol, Inst Biosci, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationINCor HC FMUSP, Discipline Allergy & Immunol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, CEPEMA POLI, BR-05508900 São Paulo, Brazil
dc.description.affiliationUNESP, IBILCE, Dept Phys, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP Rio Claro, Ctr Study Social Insects CEIS, Dept Biol, Inst Biosci, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUnespUNESP, IBILCE, Dept Phys, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipInstituto de Investigação em Imunologia - Instituto Nacional de Ciência e Tecnologia (III-INCT)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 04/07942-2
dc.description.sponsorshipIdFAPESP: 06/57122-6
dc.format.extent880-889
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2010.06.011
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 56, n. 6, p. 880-889, 2010.
dc.identifier.doi10.1016/j.toxicon.2010.06.011
dc.identifier.issn0041-0101
dc.identifier.lattes2901888624506535
dc.identifier.urihttp://hdl.handle.net/11449/19691
dc.identifier.wosWOS:000282253900004
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofToxicon
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectWasp venomen
dc.subjectToxinen
dc.subjectChemotaxisen
dc.subjectHeterodimeren
dc.subjectPeptide-membrane interactionen
dc.subjectMast cell degranulationen
dc.subjectAntibiosisen
dc.titleProtonectin (1-6): A novel chemotactic peptide from the venom of the social wasp Agelaia pallipes pallipesen
dc.typeArtigo
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.advisor.lattes2901888624506535
unesp.author.orcid0000-0002-9225-5654[5]
unesp.author.orcid0000-0002-2078-9286[6]
unesp.author.orcid0000-0001-7443-2883[7]
unesp.author.orcid0000-0002-7363-8211[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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