Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex

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dc.contributor.authorBehura, Susanta K.
dc.contributor.authorTizioto, Polyana C.
dc.contributor.authorKim, Jaewoo
dc.contributor.authorGrupioni, Natalia V. [UNESP]
dc.contributor.authorSeabury, Christopher M.
dc.contributor.authorSchnabel, Robert D.
dc.contributor.authorGershwin, Laurel J.
dc.contributor.authorVan Eenennaam, Alison L.
dc.contributor.authorToaff-Rosenstein, Rachel
dc.contributor.authorNeibergs, Holly L.
dc.contributor.authorRegitano, Luciana C. A.
dc.contributor.authorTaylor, Jeremy F.
dc.contributor.institutionUniversity of Missouri
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTexas AandM University
dc.contributor.institutionUniversity of California
dc.contributor.institutionWashington State University
dc.date.accessioned2018-12-11T17:17:03Z
dc.date.available2018-12-11T17:17:03Z
dc.date.issued2017-12-01
dc.description.abstractBovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host's immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as 'key players' within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD.en
dc.description.affiliationDivision of Animal Sciences University of Missouri
dc.description.affiliationEmbrapa Southeast Livestock
dc.description.affiliationDepartamento de Ciencias Exatas UNESP Univ Estadual Paulista Faculdade de Ciencias Agrarias e Veterinarias
dc.description.affiliationDepartment of Veterinary Pathobiology College of Veterinary Medicine Texas AandM University
dc.description.affiliationInformatics Institute University of Missouri
dc.description.affiliationDepartment of Pathology Microbiology and Immunology School of Veterinary Medicine University of California
dc.description.affiliationDepartment of Animal Science College of Agriculture University of California
dc.description.affiliationDepartment of Animal Sciences College of Agriculture Natural Resource Sciences Washington State University
dc.description.affiliationUnespDepartamento de Ciencias Exatas UNESP Univ Estadual Paulista Faculdade de Ciencias Agrarias e Veterinarias
dc.identifierhttp://dx.doi.org/10.1038/s41598-017-18205-0
dc.identifier.citationScientific Reports, v. 7, n. 1, 2017.
dc.identifier.doi10.1038/s41598-017-18205-0
dc.identifier.file2-s2.0-85038879112.pdf
dc.identifier.issn2045-2322
dc.identifier.scopus2-s2.0-85038879112
dc.identifier.urihttp://hdl.handle.net/11449/175681
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.relation.ispartofsjr1,533
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleTissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complexen
dc.typeArtigo

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