MOF-Based Erodible System for On-Demand Release of Bioactive Flavonoid at the Polymer-Tissue Interface

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dc.contributor.authorBim-Júnior, Odair [UNESP]
dc.contributor.authorGaglieri, Caroline [UNESP]
dc.contributor.authorBedran-Russo, Ana K.
dc.contributor.authorBueno-Silva, Bruno
dc.contributor.authorBannach, Gilbert [UNESP]
dc.contributor.authorFrem, Regina [UNESP]
dc.contributor.authorXimenes, Valdecir Farias [UNESP]
dc.contributor.authorLisboa-Filho, Paulo N. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Illinois at Chicago (UIC)
dc.contributor.institutionGuarulhos University (UNG)
dc.date.accessioned2020-12-12T02:22:14Z
dc.date.available2020-12-12T02:22:14Z
dc.date.issued2020-08-10
dc.description.abstractPlant-derived compounds incite applications virtually on every biomedical field due to the expedient antioxidant, anti-inflammatory and antimicrobial properties in conjunction with a natural character. Here, quercetin (QCT), a flavonoid with therapeutic potentials relevant to the oral environment, was encapsulated within metal-organic frameworks (MOFs) to address the concept of on-demand release of phytochemicals at the biointerface. We verified the applicability of a microporous MOF (ZIF-8) as a controlled-release system for QCT, as well as investigated the incorporation of QCT@ZIF-8 microparticles into a dental adhesive resin for desirable therapeutic capabilities at the tooth-restoration interface. QCT was encapsulated within the frameworks through a water-based, one-step synthetic process. The resulting QCT@ZIF-8 microparticles were characterized with respect to chemical composition, crystal structure, thermal behavior, micromorphology, and release profile under acidic and physiological conditions. A model dental adhesive formulation was enriched with the bioactive microparticles; both the degree of conversion (DC) of methacrylic double bonds and the polymer thermal behavior were accounted for. The results confirm that crystalline QCT@ZIF-8 microparticles with attractive loading capacities, submicron sizes, high thermal stability and responsiveness to environmental pH change were successfully manufactured. The concentration of QCT@ZIF-8 in the resin system was a key factor to maintain an optimal DC plateau and rate of polymerization. Essentially, one-step encapsulation of QCT in biocompatible ZIF-8 matrices can be easily achieved, and QCT@ZIF-8 microparticles proved as smart platforms to carry bioactive compounds with potential use to prevent microbial and enzymatic degradation of hard tissues and extracellular matrix components.en
dc.description.affiliationDepartment of Physics School of Sciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Chemistry School of Sciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Restorative Dentistry College of Dentistry University of Illinois at Chicago (UIC)
dc.description.affiliationDental Research Division Guarulhos University (UNG)
dc.description.affiliationDepartment of Inorganic Chemistry Institute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Physics School of Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Chemistry School of Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Inorganic Chemistry Institute of Chemistry São Paulo State University (UNESP)
dc.format.extent4539-4550
dc.identifierhttp://dx.doi.org/10.1021/acsbiomaterials.0c00564
dc.identifier.citationACS Biomaterials Science and Engineering, v. 6, n. 8, p. 4539-4550, 2020.
dc.identifier.doi10.1021/acsbiomaterials.0c00564
dc.identifier.issn2373-9878
dc.identifier.lattes8534138813417161
dc.identifier.orcid0000-0003-1574-681X
dc.identifier.scopus2-s2.0-85090498422
dc.identifier.urihttp://hdl.handle.net/11449/201027
dc.language.isoeng
dc.relation.ispartofACS Biomaterials Science and Engineering
dc.sourceScopus
dc.subjectbioactive polymer
dc.subjectcontrolled release
dc.subjectdental adhesive
dc.subjectflavonoid
dc.subjectMOFs
dc.titleMOF-Based Erodible System for On-Demand Release of Bioactive Flavonoid at the Polymer-Tissue Interfaceen
dc.typeArtigo
unesp.author.lattes8534138813417161[6]
unesp.author.orcid0000-0001-9938-9500[1]
unesp.author.orcid0000-0001-9612-6887[2]
unesp.author.orcid0000-0002-3670-9519[3]
unesp.author.orcid0000-0003-3275-5910[4]
unesp.author.orcid0000-0002-8790-5069[5]
unesp.author.orcid0000-0002-7734-4069[8]
unesp.author.orcid0000-0003-1574-681X[6]

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Artigos - Química Inorgânica - IQ