Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth

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dc.contributor.authorJasiulionis, Miriam G.
dc.contributor.authorLuchessi, Augusto D.
dc.contributor.authorMoreira, Andreia G.
dc.contributor.authorSouza, Pedro P. C.
dc.contributor.authorSuenaga, Ana P. M.
dc.contributor.authorCorrea, Mariangela
dc.contributor.authorCosta, Carlos A. S. [UNESP]
dc.contributor.authorCuri, Rui
dc.contributor.authorCosta-Neto, Claudio M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:21Z
dc.date.available2014-05-27T11:22:21Z
dc.date.issued2007-01-01
dc.description.abstractThe eukaryotic translation initiation factor 5A (eIF5A) undergoes a specific post-translational modification called hypusination. This modification is required for the functionality of this protein. The compound N1-guanyl-1,7-diaminoheptane (GC7) is a potent and selective inhibitor of deoxyhypusine synthase, which catalyses the first step of eIF5A hypusination process. In the present study, the effects of GC7 on cell death were investigated using two cell lines: melan-a murine melanocytes and Tm5 marine melanoma. In vitro treatment with GC7 increased by 3-fold the number of cells presenting DNA fragmentation in Tm5 cells. Exposure to GC7 also decreased viability to both cell lines. This study also describes, for the first time, the in vivo antitumour effect of GC7, as indicated by impaired melanoma growth in C57BL/6 mice. Copyright © 2006 John Wiley & Sons, Ltd.en
dc.description.affiliationDepartment of Micro-Immuno-Parasitology Federal University of São Paulo, 04023-062, São Paulo
dc.description.affiliationDepartment of Physiology and Biophysics Institute of Biomedical Sciences University of São Paulo, 05508-900, São Paulo
dc.description.affiliationDepartment of Biochemistry and Immunology Faculty of Medicine of Ribeirão Preto University of São Paulo, 14049-900, Ribeirão Preto
dc.description.affiliationDepartment of Physiology and Pathology Faculty of Dentistry of Araraquara UNESP, 14801-903, Araraquara
dc.description.affiliationDepartment of Biochemistry and Immunology Faculty of Medicine of Ribeirão Preto University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirao-Preto
dc.description.affiliationUnespDepartment of Physiology and Pathology Faculty of Dentistry of Araraquara UNESP, 14801-903, Araraquara
dc.format.extent109-114
dc.identifierhttp://dx.doi.org/10.1002/cbf.1351
dc.identifier.citationCell Biochemistry and Function, v. 25, n. 1, p. 109-114, 2007.
dc.identifier.doi10.1002/cbf.1351
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.scopus2-s2.0-33846292223
dc.identifier.urihttp://hdl.handle.net/11449/69436
dc.identifier.wosWOS:000243581300012
dc.language.isoeng
dc.relation.ispartofCell Biochemistry and Function
dc.relation.ispartofjcr2.186
dc.relation.ispartofsjr0,520
dc.relation.ispartofsjr0,520
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCell proliferation
dc.subjectCytotoxicity
dc.subjecteIF-5A
dc.subjecteIF5A
dc.subjectGC7
dc.subjectHypusine
dc.subjectMelanoma
dc.subjectTumour growth
dc.subjectenzyme inhibitor
dc.subjectinitiation factor 5A
dc.subjectn1 guanyl 1,7 diaminoheptane
dc.subjectunclassified drug
dc.subjectanimal cell
dc.subjectantineoplastic activity
dc.subjectcancer growth
dc.subjectcancer inhibition
dc.subjectcatalysis
dc.subjectcell death
dc.subjectcell viability
dc.subjectcontrolled study
dc.subjecthypusination
dc.subjectmelanoma
dc.subjectmelanoma cell
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein function
dc.subjectprotein processing
dc.subjectAnimals
dc.subjectCell Line, Tumor
dc.subjectCell Survival
dc.subjectDNA Fragmentation
dc.subjectFemale
dc.subjectGuanine
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectMolecular Structure
dc.subjectPeptide Initiation Factors
dc.subjectProtein Processing, Post-Translational
dc.subjectRNA-Binding Proteins
dc.subjectEukaryota
dc.subjectMurinae
dc.subjectMus
dc.titleInhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growthen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.author.lattes4517484241515548[7]
unesp.author.orcid0000-0002-7455-6867[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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