Pituitary-adrenal activity and opioid release in ponies during thiopentone/halothane anaesthesia

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dc.contributor.authorLuna, Stélio Pacca Loureiro [UNESP]
dc.contributor.authorTaylor, P. M.
dc.contributor.institutionAnimal Health Trust
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Cambridge
dc.date.accessioned2014-05-27T11:18:00Z
dc.date.available2014-05-27T11:18:00Z
dc.date.issued1995-02-01
dc.description.abstractThe effect of thiopentone/halothane anaesthesia on the release of endogenous opioid, adrenocorticotrophin, arginine vasopressin, cortisol and catecholamine was investigated in ponies. The contribution made by halothane itself was studied by maintaining six ponies with a constant 12 per cent end tidal halothane concentration and five with a concentration ranging between 0.8 and 12 per cent. Cardiorespiratory depression was more prolonged in the ponies receiving a constant 1-2 per cent end tidal halothane concentration than in those which received less halothane. Plasma lactate concentration increased and haematocrit decreased during halothane anaesthesia. The concentrations of met-enkephalin, dynorphin and catecholamines did not change and those of β-endorphin, adrenocorticotrophin, arginine vasopressin and cortisol increased during halothane anaesthesia. Halothane appeared to be a major stimulus to pituitary adrenocortical activation because the adrenocortical secretion was proportional to the amount of halothane inhaled. β-endorphin increased proportionally more than adrenocorticotrophin and their plasma concentrations were not correlated, suggesting that they have independent secretion mechanisms.en
dc.description.affiliationAnimal Health Trust, PO Box 5, Newmarket, Suffolk CB8 7DW
dc.description.affiliationDepartment of Veterinary Surgery and Animal Reproduction Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP) Campus de Botucatu, CEP 18618-000, Botucatu, São Paulo
dc.description.affiliationUniversity of Cambridge Department of Clinical Veterinary Medicine, Madingley Road, Cambridge CB3 OES
dc.description.affiliationUnespDepartment of Veterinary Surgery and Animal Reproduction Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP) Campus de Botucatu, CEP 18618-000, Botucatu, São Paulo
dc.format.extent35-41
dc.identifierhttp://dx.doi.org/10.1016/0034-5288(95)90085-3
dc.identifier.citationResearch in Veterinary Science, v. 58, n. 1, p. 35-41, 1995.
dc.identifier.doi10.1016/0034-5288(95)90085-3
dc.identifier.issn0034-5288
dc.identifier.lattes4473260410099623
dc.identifier.orcid0000-0001-5312-9076
dc.identifier.scopus2-s2.0-0028854368
dc.identifier.urihttp://hdl.handle.net/11449/64591
dc.language.isoeng
dc.relation.ispartofResearch in Veterinary Science
dc.relation.ispartofjcr1.616
dc.relation.ispartofsjr0,593
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectanesthetic agent
dc.subjectargipressin
dc.subjectbeta endorphin
dc.subjectcatecholamine
dc.subjectcorticotropin
dc.subjectdynorphin
dc.subjectendorphin
dc.subjecthalothane
dc.subjecthydrocortisone
dc.subjectmetenkephalin
dc.subjectthiopental
dc.subjectanesthesia
dc.subjectanimal experiment
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjecthormone release
dc.subjecthypophysis adrenal system
dc.subjectinhalational drug administration
dc.subjectmale
dc.subjectnonhuman
dc.subjectrespiration depression
dc.subjectAnalysis of Variance
dc.subjectAnesthesia, General
dc.subjectAnesthetics, General
dc.subjectAnimal
dc.subjectDose-Response Relationship, Drug
dc.subjectHalothane
dc.subjectHemodynamics
dc.subjectHorses
dc.subjectMale
dc.subjectOpioid Peptides
dc.subjectPituitary-Adrenal System
dc.subjectRespiration
dc.subjectSupport, Non-U.S. Gov't
dc.subjectThiopental
dc.subjectAnimalia
dc.titlePituitary-adrenal activity and opioid release in ponies during thiopentone/halothane anaesthesiaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes4473260410099623
unesp.author.orcid0000-0001-5312-9076[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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