Transcription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA protein in response to acid pH-sensing in the fungus Aspergillus nidulans

Página do item simplificado
dc.contributor.authorFreitas, Janana S.
dc.contributor.authorSilva, Emiliana M.
dc.contributor.authorLeal, Juliana
dc.contributor.authorGras, Diana E.
dc.contributor.authorMartinez-Rossi, Nilce M.
dc.contributor.authordos Santos, Lucilene Delazari [UNESP]
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.authorRossi, Antonio
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:12:48Z
dc.date.available2014-05-20T13:12:48Z
dc.date.issued2011-09-01
dc.description.abstractHeat shock proteins are molecular chaperones linked to a myriad of physiological functions in both prokaryotes and eukaryotes. In this study, we show that the Aspergillus nidulans hsp30 (ANID_03555.1), hsp70 (ANID_05129.1), and hsp90 (ANID_08269.1) genes are preferentially expressed in an acidic milieu, whose expression is dependent on the palA (+) background under optimal temperature for fungal growth. Heat shock induction of these three hsp genes showed different patterns in response to extracellular pH changes in the palA(+) background. However, their accumulation upon heating for 2 h was almost unaffected by ambient pH changes in the palA (-) background. The PalA protein is a member of a conserved signaling cascade that is involved in the pH-mediated regulation of gene expression. Moreover, we identified several genes whose expression at pH 5.0 is also dependent on the palA (+) background. These results reveal novel aspects of the heat- and pH-sensing networks of A. nidulans.en
dc.description.affiliationUniv São Paulo, Dept Bioquim & Imunol, Fac Med Ribeirao & Preto, BR-14049900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Genet, Fac Med Ribeirao & Preto, BR-14049900 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Ctr Estudos Insetos Sociais, Dept Biol, Inst Biociencias, BR-13506900 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Ctr Estudos Insetos Sociais, Dept Biol, Inst Biociencias, BR-13506900 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (FAEPA)
dc.format.extent565-572
dc.identifierhttp://dx.doi.org/10.1007/s12192-011-0267-5
dc.identifier.citationCell Stress & Chaperones. Dordrecht: Springer, v. 16, n. 5, p. 565-572, 2011.
dc.identifier.doi10.1007/s12192-011-0267-5
dc.identifier.issn1355-8145
dc.identifier.lattes2901888624506535
dc.identifier.urihttp://hdl.handle.net/11449/729
dc.identifier.wosWOS:000293965500009
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofCell Stress & Chaperones
dc.relation.ispartofjcr2.571
dc.relation.ispartofsjr0,987
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAspergillus nidulansen
dc.subjectpH sensingen
dc.subjectpal signaling pathwayen
dc.subjectHSPen
dc.titleTranscription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA protein in response to acid pH-sensing in the fungus Aspergillus nidulansen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes2901888624506535

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Rio Claro - CEIS - Centro de Estudos de Insetos Sociais