Zona thinning with a noncontact diode laser in ICSI embryos from women of advanced age

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dc.contributor.authorPetersen, C. G.
dc.contributor.authorMauri, A. L.
dc.contributor.authorBaruffi, RLR
dc.contributor.authorPontes, Anaglória [UNESP]
dc.contributor.authorFranco, J. G.
dc.contributor.institutionSinha Junqueira Matern Fdn
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Ribeirao Preto
dc.date.accessioned2014-05-20T13:35:07Z
dc.date.available2014-05-20T13:35:07Z
dc.date.issued2002-11-01
dc.description.abstractPurpose: the objective of this study was to determine if the zona thinning (ZT) technique improved the rates of implantation and clinical pregnancy for patients aged, greater than or equal to38 years submitted to an ICSI program.Methods: A total of 100 patients submitted to ICSI and aged, greater than or equal to38 years were divided in a prospective and randomized manner into two groups: Group I - patients submitted to ZT (n = 50); a laser diode with 1.48 mum wavelength (Fertilaser) was used for the ZT procedure with 1-2 irradiations of 10 ms applied to four different positions on the zona pellucida (ZP) of each embryo to thin 60-90% of the ZP (each point with a 15-20 mum length of ZT). Group II - patients with no ZT (n = 50). In both groups, embryo transfer was performed on the second or third day.Results: the age of Group I patients (39.8 +/- 1.3) did not differ (p = 0.67) from that of Group II patients (40 +/- 1.9). The number of oocytes retrieved at metaphase II from Group I (6.4 +/- 4.2) and Group II (6.8 +/- 5) was similar (p = 0.94). Normal fertilization rates and cleavage rates were similar (p = 0.78 and p = 0.63, respectively) for Group I (71.5 +/- 22% and 96.7 +/- 11%) and Group II (73.5 +/- 19.7% and 96 +/- 11%, respectively). The number of embryos transferred was similar (p = 0.53) for the two groups (Group I = 3.1 +/- 1.3; Group II = 2.9 +/- 1.1). The thickness of the ZP of Group I embryos (16.9 +/- 2.4 mum) did not differ (p = 0.97) from that of Group II embryos (16.9 +/- 2.3 mum). The rates of embryo implantation and clinical pregnancy per embryo transfer were similar (p = 0.67, p = 0.61) for Group I (7 and 16%, respectively) and for Group II (8.2 and 22%, respectively).Conclusions: These results suggest that ZT in the population aged, 38 years may have no impact on ICSI success rates. However, this conclusion is limited to a situation in which length of the laser ZT was less than or equal to 20 mum and the laser was applied to four different positions.en
dc.description.affiliationSinha Junqueira Matern Fdn, Ctr Human Reprod, BR-14085100 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Dept Gynecol & Obstet, Fac Med, Botucatu, SP, Brazil
dc.description.affiliationUniv Ribeirao Preto, Dept Obstet & Gynecol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Dept Gynecol & Obstet, Fac Med, Botucatu, SP, Brazil
dc.format.extent512-516
dc.identifierhttp://dx.doi.org/10.1023/A:1020907801849
dc.identifier.citationJournal of Assisted Reproduction and Genetics. New York: Kluwer Academic/plenum Publ, v. 19, n. 11, p. 512-516, 2002.
dc.identifier.doi10.1023/A:1020907801849
dc.identifier.issn1058-0468
dc.identifier.lattes0514178654667684
dc.identifier.urihttp://hdl.handle.net/11449/12063
dc.identifier.wosWOS:000178996100002
dc.language.isoeng
dc.publisherKluwer Academic/plenum Publ
dc.relation.ispartofJournal of Assisted Reproduction and Genetics
dc.relation.ispartofjcr2.788
dc.relation.ispartofsjr1,179
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectadvanced agept
dc.subjectassisted hatchingpt
dc.subjectimplantationpt
dc.subjectintracytoplasmic sperm injectionpt
dc.subjectlaserpt
dc.subjectpregnancypt
dc.subjectzona thinningpt
dc.titleZona thinning with a noncontact diode laser in ICSI embryos from women of advanced ageen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dcterms.rightsHolderKluwer Academic/plenum Publ
unesp.author.lattes0514178654667684
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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