Immunoexpression of angiogenesis and proliferation markers in patients treated with cyclosporin A

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dc.contributor.authorAfonso, M. [UNESP]
dc.contributor.authorPerrotti, V.
dc.contributor.authorRapani, M.
dc.contributor.authorIaculli, F.
dc.contributor.authorPiccirilli, M.
dc.contributor.authorOnuma, T.
dc.contributor.authorShibli, J. A.
dc.contributor.authorOliveira Bello, V. de
dc.contributor.authorSposto, M. R.
dc.contributor.authorArtese, L.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Chieti‑Pescara Chieti
dc.contributor.institutionUniversidade de Guarulhos (UNG)
dc.date.accessioned2015-12-07T15:30:39Z
dc.date.available2015-12-07T15:30:39Z
dc.date.issued2014
dc.description.abstractIn the present immunohistochemical study, the expression of vascular endothelial growth factor, nitric oxide synthase 1 and 3, and Ki-67 in the gingival tissues of renal transplant patients treated with cyclosporin A was assessed. Gingival overgrowth (GO) frequently occurs in transplant patients receiving immunosuppressive drugs such as cyclosporine and this gingival inflammation might play an important role in the pathogenesis of drug-induced GO. Twenty-eight human gingival biopsies were taken from healthy patients with chronic periodontitis (N.=14 control group), and from renal transplant recipients treated with cyclosporin A (N.=14 test group). The retrieved specimens were immunohistochemically processed and stained for vascular endothelial growth factor, nitric oxide synthase 1 and 3, and Ki-67. The levels of vascular endothelial growth factor, nitric oxide synthase 1 and 3, and Ki-67 were found to be significantly different among groups (P>0.001), with patients treated with cyclosporin A showing higher levels of all the analyzed markers compared to control group. In summary, the data from this pilot study suggests that the investigated factors have a role in the inflammation processes associated to immunosuppressive therapy. However, further studies with a larger sample population need to be conducted for an exhaustive knowledge of the mechanisms leading to GO.en
dc.description.affiliationDepartment of Diagnosis and Oral Surgery Araraquara Dental School, UNESP Araraquara, SP, Brazil
dc.description.affiliationDepartment of Medical, Oral and Biotechnological Sciences Dental School, University of Chieti‑Pescara Chieti, Italy
dc.description.affiliationDepartment of Periodontology Dental Research Division, Guarulhos University Guarulhos, SP, Brazil
dc.description.affiliationKidney Transplant Unit Base Hospital, Brasilia, Brazil.
dc.description.affiliationUnespDepartment of Diagnosis and Oral Surgery Araraquara Dental School, UNESP Araraquara, SP, Brazil - v.perrotti@unich.it.
dc.format.extent59-67
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24632797
dc.identifier.citationMinerva Stomatologica, v. 63, n. 3, p. 59-67, 2014.
dc.identifier.issn0026-4970
dc.identifier.pubmed24632797
dc.identifier.urihttp://hdl.handle.net/11449/130990
dc.language.isoeng
dc.publisherMinerva Medica
dc.relation.ispartofMinerva Stomatologica
dc.relation.ispartofsjr0,301
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.titleImmunoexpression of angiogenesis and proliferation markers in patients treated with cyclosporin Aen
dc.typeArtigo
dcterms.rightsHolderMinerva Medica
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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