Cissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activities

Página do item simplificado
dc.contributor.authorBeserra, Fernando Pereira [UNESP]
dc.contributor.authorde Cássia Santos, Raquel
dc.contributor.authorPérico, Larissa Lucena [UNESP]
dc.contributor.authorRodrigues, Vinicius Peixoto [UNESP]
dc.contributor.authorde Almeida Kiguti, Luiz Ricardo [UNESP]
dc.contributor.authorSaldanha, Luiz Leonardo [UNESP]
dc.contributor.authorPupo, André Sampaio [UNESP]
dc.contributor.authorda Rocha, Lúcia Regina Machado [UNESP]
dc.contributor.authorDokkedal, Anne Lígia [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade São Francisco
dc.date.accessioned2018-12-11T17:00:28Z
dc.date.available2018-12-11T17:00:28Z
dc.date.issued2016-01-23
dc.description.abstractThe objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smoothmuscle and/or intestinal transit.en
dc.description.affiliationDepartamento de Fisiologia Instituto de Biociências Universidade Estadual Paulista—UNESP
dc.description.affiliationUnidade Integrada de Farmacologia e Gastroenterologia Universidade São Francisco
dc.description.affiliationDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista—UNESP
dc.description.affiliationDepartamento de Ciências Biológicas Universidade Estadual Paulista—UNESP
dc.description.affiliationDepartamento de Botânica Instituto de Biociências Universidade Estadual Paulista—UNESP
dc.description.affiliationCampus Experimental do Litoral Paulista Universidade Estadual Paulista-UNESP
dc.description.affiliationUnespDepartamento de Fisiologia Instituto de Biociências Universidade Estadual Paulista—UNESP
dc.description.affiliationUnespDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista—UNESP
dc.description.affiliationUnespDepartamento de Ciências Biológicas Universidade Estadual Paulista—UNESP
dc.description.affiliationUnespDepartamento de Botânica Instituto de Biociências Universidade Estadual Paulista—UNESP
dc.description.affiliationUnespCampus Experimental do Litoral Paulista Universidade Estadual Paulista-UNESP
dc.identifierhttp://dx.doi.org/10.3390/ijms17020149
dc.identifier.citationInternational Journal of Molecular Sciences, v. 17, n. 2, 2016.
dc.identifier.doi10.3390/ijms17020149
dc.identifier.file2-s2.0-84955575355.pdf
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.scopus2-s2.0-84955575355
dc.identifier.urihttp://hdl.handle.net/11449/172466
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.ispartofsjr1,260
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAnti-inflammatory
dc.subjectAntidiarrheal
dc.subjectCissus sicyoides
dc.subjectPGE2
dc.subjectVitaceae
dc.titleCissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activitiesen
dc.typeArtigo
unesp.author.lattes2224433126054725[7]
unesp.author.lattes5569977655658319[9]
unesp.author.lattes3814504901386844[11]
unesp.author.orcid0000-0001-6627-3448[7]
unesp.author.orcid0000-0002-0213-8551[9]
unesp.author.orcid0000-0002-8645-3777[11]

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
2-s2.0-84955575355.pdf
Tamanho:
1.52 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar

Coleções

Artigos - Ciências Biológicas - São Vicente