Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety

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dc.contributor.authorFlausino, Otavio Aparecido
dc.contributor.authorPereira, Ana Maria
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorNunes-de-Souza, Ricardo Luiz
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Ribeirao Preto
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T15:23:24Z
dc.date.available2014-05-20T15:23:24Z
dc.date.issued2007-02-01
dc.description.abstractThe effects of acute oral administration of erythrinian alkaloids, Le. (+)-alpha-hydroxy-erysotrine, erythravine and (+)-11 alpha-hydroxy-erythravine isolated from the flowers of Erythrina mulungu were investigated in two animal models of anxiety in mice-the light-dark transition model (LDTM) and the elevated plus-maze (EPM). In the LDTM, erythravine (3, 10 mg/kg) and (+)-11 alpha-hydroxy-erythravine (10mg/kg) increased the time spent by the animals in the illuminated compartment and (+)-11 alpha-hydroxy-erythravine (3 mg/kg) increased the number of transitions between compartments of the LDTM, suggesting an anxiolytic-like effect of these erythrinian alkaloids. Nevertheless, the third alkaloid studied, (+)-alpha-hydroxy-erysotrine, did not change any behavioral response with the range of doses used (3-10 mg/kg). Since the oral administration of the crude extract of E. mulungu (EM) (100-400 mg/kg) did not modify the conventional measures of anxiety in the EPM, this animal model was not chosen to evaluate the anxiolytic properties of the isolated alkaloids. These results suggest that the alkaloids erythravine and (+)-11 alpha-hydroxy-erythravine are responsible for the anxiolytic effects of the crude extract of E. mulungu.en
dc.description.affiliationSão Paulo State Univ, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Organ Chem, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Ribeirao Preto, Dept Vegetal Biotechnol, BR-14096380 Ribeirao Preto, Brazil
dc.description.affiliationUniv São Paulo, FFCLRP, Dept Psychobiol, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Organ Chem, BR-14801902 Araraquara, SP, Brazil
dc.format.extent375-378
dc.identifierhttp://dx.doi.org/10.1248/bpb.30.375
dc.identifier.citationBiological & Pharmaceutical Bulletin. Tokyo: Pharmaceutical Soc Japan, v. 30, n. 2, p. 375-378, 2007.
dc.identifier.doi10.1248/bpb.30.375
dc.identifier.fileWOS000245582600032.pdf
dc.identifier.issn0918-6158
dc.identifier.lattes4484083685251673
dc.identifier.scopus2-s2.0-33846988259
dc.identifier.urihttp://hdl.handle.net/11449/34195
dc.identifier.wosWOS:000245582600032
dc.language.isoeng
dc.publisherPharmaceutical Soc Japan
dc.relation.ispartofBiological & Pharmaceutical Bulletin
dc.relation.ispartofjcr1.694
dc.relation.ispartofsjr0,626
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectErythrina mulungupt
dc.subjectalkaloidpt
dc.subjectanxietypt
dc.subjectmedicinal plantpt
dc.subjectcentral nervous systempt
dc.subjectanimal modelpt
dc.titleEffects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxietyen
dc.typeArtigo
dcterms.licensehttp://bpb.pharm.or.jp/document/transfer.pdf
dcterms.rightsHolderPharmaceutical Soc Japan
unesp.author.lattes4484083685251673
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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