The relationship between Vitamin D status and exacerbation in COPD patients– a literature review

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dc.contributor.authorFerrari, Renata [UNESP]
dc.contributor.authorCaram, Laura M.O. [UNESP]
dc.contributor.authorTanni, Suzana E. [UNESP]
dc.contributor.authorGodoy, Irma [UNESP]
dc.contributor.authorRupp de Paiva, Sergio Alberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:19:48Z
dc.date.available2018-12-11T17:19:48Z
dc.date.issued2018-06-01
dc.description.abstractObjective: To investigate the relationship between Vitamin D and exacerbation in COPD patients. Methods: The PubMed database was searched for articles published from 2012 onwards using search terms related to Vitamin D and exacerbation in COPD patients. Meta-analysis, clinical trials, observational studies, and human studies were included. Non-English articles or articles with full text unavailable were excluded; a total of 15 articles were selected. Results: The association between exacerbation frequency and Vitamin D levels in observational studies remains controversial, however, meta-analysis revealed a negative association between serum Vitamin D and exacerbation. Also, two clinical trials showed that Vitamin D3 supplementation in COPD patients reduced the risk of moderate and severe exacerbation. Vitamin D binding protein (VDBP) polymorphisms seem to affect patient exacerbation susceptibility. Conclusions: Few studies in literature have data related to diet, 25-hydroxyVitamin D [25(OH)D] and polymorphism in COPD exacerbation. One clinical trial indicates Vitamin D supplementation plays a role in COPD patients with hypovitaminosis D in preventing exacerbations. Further studies are needed to elucidate the role of Vitamin D in this population and to establish the best marker for Vitamin D, which patient subgroups will benefit, and the best supplement dosage without leading to toxicity.en
dc.description.affiliationBotucatu Medical School UNESP – Univ Estadual Paulista Botucatu Campus Department of Internal Medicine Pneumology Area
dc.description.affiliationBotucatu Medical School UNESP – Univ Estadual Paulista
dc.description.affiliationBotucatu Medical School UNESP – Univ Estadual Paulista Botucatu Campus Department of Internal Medicine Internal Medicine Area
dc.description.affiliationUnespBotucatu Medical School UNESP – Univ Estadual Paulista Botucatu Campus Department of Internal Medicine Pneumology Area
dc.description.affiliationUnespBotucatu Medical School UNESP – Univ Estadual Paulista
dc.description.affiliationUnespBotucatu Medical School UNESP – Univ Estadual Paulista Botucatu Campus Department of Internal Medicine Internal Medicine Area
dc.format.extent34-38
dc.identifierhttp://dx.doi.org/10.1016/j.rmed.2018.04.012
dc.identifier.citationRespiratory Medicine, v. 139, p. 34-38.
dc.identifier.doi10.1016/j.rmed.2018.04.012
dc.identifier.file2-s2.0-85046356221.pdf
dc.identifier.issn1532-3064
dc.identifier.issn0954-6111
dc.identifier.scopus2-s2.0-85046356221
dc.identifier.urihttp://hdl.handle.net/11449/176255
dc.language.isoeng
dc.relation.ispartofRespiratory Medicine
dc.relation.ispartofsjr1,472
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectChronic obstructive pulmonary disease
dc.subjectExacerbation
dc.subjectPolymorphisms
dc.subjectSupplementation
dc.subjectVitamin D
dc.titleThe relationship between Vitamin D status and exacerbation in COPD patients– a literature reviewen
dc.typeResenha
unesp.author.orcid0000-0002-5863-2006[2]

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Artigos - Clínica Médica - FMB