Fever response induced by intravenous and intracerebrovascular injection of pyrogen in thyroidectomised and protein-calorie malnourished rabbits

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dc.contributor.authorMacari, Marcos [UNESP]
dc.contributor.authorPela, I. R. [UNESP]
dc.contributor.authorSilva, C. A A [UNESP]
dc.contributor.authorViana, R. S. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T08:07:09Z
dc.date.available2014-05-27T08:07:09Z
dc.date.issued1990-02-14
dc.description.abstractThe development of a fever in response to intravenous (IV, 1.5 μg/kg body mass) and intracerebroventricular (ICV, 1.5 μg/animal) injections of Escherichia coli lipopolysaccharide (LPS) was studied in control, thyroidectomised and protein-calorie malnourished rabbits (New Zealand Whites, n = 55). ICV injection of LPS is control rabbits produced a fever response, the characteristics of which differed from those obtained after IV pyrogen injection. Thyroid deficiency caused an attenuated fever response, irrespective of whether LPS had been administered by IV or ICV injection. Protein-calorie malnourished rabbits showed a smaller fever response after IV or ICV pyrogen injections. Malnourished rabbits, refed over a period of 15 days, showed a typical biphasic fever response, but with lower magnitude than controls. The results of these experiments suggest that ICV injection of LPS is not an appropriate model for the study of fever mechanisms in disease states, and that the attenuated fever response observed in protein-calorie malnourished rabbits may be related, at least in part, to a decreased ability to produce the endogenous pyrogen interleukin-1.en
dc.description.affiliationDept. Morfol./Fisiol. Animal Fac. Ciencias Agrarias UNESP, 14.870 Sao Paulo, SP
dc.description.affiliationUnespDept. Morfol./Fisiol. Animal Fac. Ciencias Agrarias UNESP, 14.870 Sao Paulo, SP
dc.format.extent440-443
dc.identifierhttp://dx.doi.org/10.1007/BF00373621
dc.identifier.citationPflugers Archiv European Journal of Physiology, v. 415, n. 4, p. 440-443, 1990.
dc.identifier.doi10.1007/BF00373621
dc.identifier.issn0031-6768
dc.identifier.lattes5713558572926669
dc.identifier.scopus2-s2.0-0025101561
dc.identifier.urihttp://hdl.handle.net/11449/63968
dc.language.isoeng
dc.relation.ispartofPflugers Archiv: European Journal of Physiology
dc.relation.ispartofjcr2.765
dc.relation.ispartofsjr1,479
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectFever
dc.subjectInterleukin-1
dc.subjectMalnutrition
dc.subjectProtein-calorie
dc.subjectRabbit
dc.subjectThyroid deficiency
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectcaloric restriction
dc.subjectfever
dc.subjectintracerebroventricular drug administration
dc.subjectintravenous drug administration
dc.subjectmale
dc.subjectmalnutrition
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein deficiency
dc.subjectrabbit
dc.subjectthermoregulation
dc.subjectthyroidectomy
dc.subjectAnimal
dc.subjectEscherichia coli
dc.subjectInjections, Intravenous
dc.subjectInjections, Intraventricular
dc.subjectLipopolysaccharides
dc.subjectMale
dc.subjectProtein-Energy Malnutrition
dc.subjectPyrogens
dc.subjectRabbits
dc.subjectSupport, Non-U.S. Gov't
dc.subjectThyroidectomy
dc.titleFever response induced by intravenous and intracerebrovascular injection of pyrogen in thyroidectomised and protein-calorie malnourished rabbitsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
unesp.author.lattes5713558572926669
unesp.author.orcid0000-0002-6850-7145[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Morfologia e Fisiologia Animal - FCAV