Histopathological alterations in the prostates of Mongolian gerbils exposed to a high-fat diet and di-n-butyl phthalate individually or in combination

Página do item simplificado
dc.contributor.authorJesus, Mariana Marcielo de
dc.contributor.authorNegrin, Ana Carolina
dc.contributor.authorTaboga, Sebastiao Roberto [UNESP]
dc.contributor.authorPinto-Fochi, Maria Etelvina [UNESP]
dc.contributor.authorGoes, Rejane Maira [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-21T13:13:45Z
dc.date.available2015-10-21T13:13:45Z
dc.date.issued2015-04-01
dc.description.abstractBoth high-fat diet and exposure to endocrine-disrupting chemicals have been implicated in susceptibility to pathological prostate lesions, but the consequences of combining the two have not yet been examined. We evaluated the effects of gestational and postnatal exposure to a high-fat diet (20% fat) and low doses of di-n-butyl phthalate (DBP; 5 mg/kg/day), individually or in combination, on the tissue response and incidence of pathological lesions in the ventral prostate of adult gerbils. Continuous intake of a high-fat diet caused dyslipidemia, hypertrophy, and promoted the development of inflammatory, premalignant and malignant prostate lesions, even in the absence of obesity. Life-time DBP exposure was obesogenic and dyslipidemic and increased the incidence of premalignant prostate lesions. Combined exposure to DBP and a high-fat diet also caused prostate hypertrophy, but the effects were less severe than those of individual treatments; combined exposure neither induced an inflammatory response nor altered serum lipid content. (C) 2015 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Biol, Dept Funct &Struct Biol, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Biol, Inst Biosci Humanities &Exact Sci, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUnespDepartment of Biology, Institute of Biosciences, Humanities and Exact Sciences, Univ Estadual Paulista (UNESP), São José do Rio Preto, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 306258/2011
dc.description.sponsorshipIdFAPESP: 2011/01612-4
dc.description.sponsorshipIdFAPESP: 2009/16071-9
dc.description.sponsorshipIdFAPESP: 2011/16316-1
dc.description.sponsorshipIdFAPESP: 2011/16406-0
dc.format.extent26-39
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0890623815000179
dc.identifier.citationReproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 52, p. 26-39, 2015.
dc.identifier.doi10.1016/j.reprotox.2015.02.005
dc.identifier.issn0890-6238
dc.identifier.lattes1445259468526188
dc.identifier.lattes0947193347312157
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0002-3622-460X
dc.identifier.urihttp://hdl.handle.net/11449/128801
dc.identifier.wosWOS:000354756100004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofReproductive Toxicology
dc.relation.ispartofjcr2.580
dc.relation.ispartofsjr0,846
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectProstateen
dc.subjectMongolian gerbilen
dc.subjectHigh-fat dieten
dc.subjectDi-n-butyl phthalateen
dc.subjectHistopathological lesionsen
dc.subjectInflammatory disordersen
dc.subjectProstatic intraepithelial neoplasiaen
dc.subjectMicroinvasive carcinomaen
dc.titleHistopathological alterations in the prostates of Mongolian gerbils exposed to a high-fat diet and di-n-butyl phthalate individually or in combinationen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1445259468526188
unesp.author.lattes0947193347312157[5]
unesp.author.orcid0000-0002-0970-4288[3]
unesp.author.orcid0000-0002-3622-460X[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

Arquivos

Coleções

Artigos - Biologia - IBILCE