Prospective and Randomized Evaluation of ChronOS and Bio-Oss in Human Maxillary Sinuses: Histomorphometric and Immunohistochemical Assignment for Runx2, Vascular Endothelial Growth Factor, and Osteocalcin

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dc.contributor.authorBonardi, Joao Paulo [UNESP]
dc.contributor.authorPereira, Rodrigo dos Santos [UNESP]
dc.contributor.authorJorge Boos Lima, Fernanda Brasil Daura
dc.contributor.authorFaverani, Leonardo Perez [UNESP]
dc.contributor.authorGriza, Geraldo Luiz [UNESP]
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.authorHochuli-Vieira, Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2018-11-29T06:33:40Z
dc.date.available2018-11-29T06:33:40Z
dc.date.issued2018-02-01
dc.description.abstractPurpose: The aim of this study was to compare ChronOS (beta-tricalcium phosphate), Bio-Oss, and their addition to an autogenous bone graft in a 1: 1 ratio in human maxillary sinus bone augmentation. Materials and Methods: Thirty maxillary sinuses were divided in 5 groups: group 1 included 6 maxillary sinuses grafted with autogenous bone graft alone; group 2 included 6 maxillary sinuses grafted with ChronOS; group 3 included 6 maxillary sinuses grafted with ChronOS and autogenous bone graft in a 1: 1 ratio; group 4 included 6 maxillary sinuses grafted with Bio-Oss; and group 5 included 6 maxillary sinuses grafted with Bio-Oss and autogenous bone graft in a 1: 1 ratio. The number of samples for each group was determined by the statistical power test. Results: The median areas of new bone formation in groups 1, 2, 3, 4, and 5 were 121,917.0, 83,787.0, 99,295.0, 65,717.0, and 56,230.0 mu m(2), respectively. Statistically significant differences were found between groups 3 and 5, groups 1 and 4, and groups 1 and 5 (P <.05). The median areas of remaining biomaterial were 2,900.5, 5,291.0, 2,662.0, 56,258.5, and 64,753.5 mu m(2) in groups 1, 2, 3, 4 and 5, respectively. Statistically significant differences occurred between groups 1 and 5, groups 3 and 5, and groups 2 and 5 (P <.05). Areas of connective tissue were 67,829.0 +/- 22,984.6 mu m(2) in group 1, 97,445.9 +/- 18,983.3 mu m(2) in group 2, 88,256.0 +/- 21,820.5 mu m(2) in group 3, 65,501.8 +/- 6,297.6 in group 4, and 70,203.2 +/- 13,421.3 mu m(2) in group 5. Conclusions: ChronOS combined with autogenous bone graft presented a behavior similar to that of autogenous bone graft alone. However, the groups treated with Bio-Oss showed immuno-labeling results indicating maturation of grafted bone. (C) 2017 American Association of Oral and Maxillofacial Surgeonsen
dc.description.affiliationUniv Estadual Paulista, Surg & Integrated Clin Dept, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Clin Pathol & Surg, Belo Horizonte, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Surg & Integrated Clin Dept, Sao Paulo, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/08455-4
dc.description.sponsorshipIdFAPESP: 2012/10028-7
dc.format.extent325-335
dc.identifierhttp://dx.doi.org/10.1016/j.joms.2017.09.020
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery. Philadelphia: W B Saunders Co-elsevier Inc, v. 76, n. 2, p. 325-335, 2018.
dc.identifier.doi10.1016/j.joms.2017.09.020
dc.identifier.fileWOS000423459200017.pdf
dc.identifier.issn0278-2391
dc.identifier.lattes1527011976590326
dc.identifier.urihttp://hdl.handle.net/11449/165977
dc.identifier.wosWOS:000423459200017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal Of Oral And Maxillofacial Surgery
dc.relation.ispartofsjr0,967
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleProspective and Randomized Evaluation of ChronOS and Bio-Oss in Human Maxillary Sinuses: Histomorphometric and Immunohistochemical Assignment for Runx2, Vascular Endothelial Growth Factor, and Osteocalcinen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1527011976590326
unesp.author.lattes6853485483683678[7]
unesp.author.orcid0000-0002-6773-6966[6]
unesp.author.orcid0000-0003-4040-9313[7]

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