Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer

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dc.contributor.authorSiufi Neto, João
dc.contributor.authorKho, Rosanne M.
dc.contributor.authordos Santos Siufi, Daniela Freitas
dc.contributor.authorBaracat, Edmund Chada
dc.contributor.authorAnderson, Karen S.
dc.contributor.authorAbrão, Maurício Simões
dc.contributor.institutionMayo Clinic Arizona
dc.contributor.institutionArizona State University
dc.contributor.institutionUniversity of the State of São Paulo
dc.date.accessioned2022-04-29T08:44:45Z
dc.date.available2022-04-29T08:44:45Z
dc.date.issued2014-01-01
dc.description.abstractOur understanding of the pathogenesis of endometriosis is rapidly evolving as early molecular events are increasingly identified. Endometriosis is associated with increased risk of ovarian cancer and exhibits neoplastic phenotypes including invasion of stromal tissue and lymphatic spread to distant organs. This review of the literature establishes the clinical, epidemiologic, and pathologic correlation between endometriosis and low-grade ovarian cancer. Genetic studies have demonstrated that endometriotic lesions have mutations in genes directly related to neoplasms, in particular the p53, KRAS, PTEN, and ARID1A genes, which suggests a direct transition from a subset of endometriotic lesions to invasive carcinomas. The identification of both genetic and epigenetic biomarkers including microRNAs are essential for identifying patients at risk for the transition to neoplasia. © 2014 AAGL.en
dc.description.affiliationDepartment of Research Mayo Clinic Arizona, Phoenix
dc.description.affiliationDepartment of Surgical Gynecology Mayo Clinic Arizona, Phoenix
dc.description.affiliationBiodesign Institute Arizona State University, Tempe
dc.description.affiliationDepartment of Obstetrics and Gynecology University of the State of São Paulo, São Paulo
dc.format.extent55-63
dc.identifierhttp://dx.doi.org/10.1016/j.jmig.2013.07.021
dc.identifier.citationJournal of Minimally Invasive Gynecology, v. 21, n. 1, p. 55-63, 2014.
dc.identifier.doi10.1016/j.jmig.2013.07.021
dc.identifier.issn1553-4650
dc.identifier.issn1553-4669
dc.identifier.scopus2-s2.0-84891145065
dc.identifier.urihttp://hdl.handle.net/11449/231312
dc.language.isoeng
dc.relation.ispartofJournal of Minimally Invasive Gynecology
dc.sourceScopus
dc.subjectEndometriosis
dc.subjectMicroRNA
dc.subjectMolecular alterations
dc.subjectOvarian cancer
dc.titleCellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Canceren
dc.typeResenha

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