Tigecycline: A Review of Properties, Applications, and Analytical Methods

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dc.contributor.authorda Silva, Lucelia Magalhaes [UNESP]
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:52Z
dc.date.available2014-05-20T13:24:52Z
dc.date.issued2010-06-01
dc.description.abstractTigecycline is a new glycylcycline with an expanded broad-spectrum antibiotic, including inhibition of Gram-positive, Gram-negative, atypical, anaerobic, and antibiotic-resistant organisms. Trials have demonstrated that tigecycline is noninferior to the comparators for the treatment of complicated skin and skin structure infections as well as complicated intra-abdominal infections. Tigecycline is only available as an intravenous preparation and analytical methods to its quantitation in pharmaceutical products has not been published to date. This review examined tigecycline characteristics, the spectrum and mechanism of action, pharmacokinetics, applications, and, mainly, the instrumental conditions of published chromatographic methods used to measure tigecycline, its metabolites, and some analogs in clinical and biologic research.en
dc.description.affiliationUNESP, Programa Posgrad Ciencias Farmaceut, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Dept Drugs & Med, Fac Pharmaceut Sci Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Programa Posgrad Ciencias Farmaceut, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Drugs & Med, Fac Pharmaceut Sci Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.format.extent282-288
dc.identifierhttp://dx.doi.org/10.1097/FTD.0b013e3181dda54f
dc.identifier.citationTherapeutic Drug Monitoring. Philadelphia: Lippincott Williams & Wilkins, v. 32, n. 3, p. 282-288, 2010.
dc.identifier.doi10.1097/FTD.0b013e3181dda54f
dc.identifier.issn0163-4356
dc.identifier.urihttp://hdl.handle.net/11449/7830
dc.identifier.wosWOS:000278379400010
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofTherapeutic Drug Monitoring
dc.relation.ispartofjcr2.092
dc.relation.ispartofsjr0,656
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectglycylcyclineen
dc.subjecttigecyclineen
dc.subjectanalytical methodsen
dc.subjectbroad-spectrum antibioticen
dc.titleTigecycline: A Review of Properties, Applications, and Analytical Methodsen
dc.typeArtigo
dcterms.licensehttp://journals.lww.com/_layouts/oaks.journals/nih.aspx
dcterms.rightsHolderLippincott Williams & Wilkins
unesp.author.orcid0000-0002-0385-340X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR