Effects of methadone on the minimum alveolar concentration of isoflurane in dogs

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dc.contributor.authorCredie, Renato G. [UNESP]
dc.contributor.authorTeixeira Neto, Francisco José [UNESP]
dc.contributor.authorFerreira, Tatiana H. [UNESP]
dc.contributor.authorAguiar, Antonio J. A. [UNESP]
dc.contributor.authorRestitutti, Fabio C.
dc.contributor.authorCorrente, Jose E. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Helsinki
dc.date.accessioned2014-05-20T13:39:12Z
dc.date.available2014-05-20T13:39:12Z
dc.date.issued2010-05-01
dc.description.abstractObjective To investigate the effects of methadone on the minimum alveolar concentration of isoflurane (ISO(MAC)) in dogs.Study design Prospective, randomized cross-over experimental study.Animals Six adult mongrel dogs, four males and two females, weighing 22.8 +/- 6.6 kg.Methods Animals were anesthetized with isoflurane and mechanically ventilated on three separate days, at least 1 week apart. Core temperature was maintained between 37.5 and 38.5 degrees C during ISO(MAC) determinations. on each study day, ISO(MAC) was determined using electrical stimulation of the antebrachium (50 V, 50 Hz, 10 mseconds) at 2.5 and 5 hours after intravenous injection of physiological saline (control) or one of two doses of methadone (0.5 or 1.0 mg kg(-1)).Results Mean (+/- SD) ISO(MAC) in the control treatment was 1.19 +/- 0.15% and 1.18 +/- 0.15% at 2.5 and 5 hours, respectively. The 1.0 mg kg(-1) dose of methadone reduced ISO(MAC) by 48% (2.5 hours) and by 30% (5 hours), whereas the 0.5 mg kg(-1) dose caused smaller reductions in ISO(MAC) (35% and 15% reductions at 2.5 and 5 hours, respectively). Both doses of methadone decreased heart rate (HR), but the 1.0 mg kg(-1) dose was associated with greater negative chronotropic actions (HR 37% lower than control) and mild metabolic acidosis at 2.5 hours. Mean arterial pressure increased in the MET1.0 treatment (13% higher than control) at 2.5 hours.Conclusions and clinical relevance Methadone reduces ISO(MAC) in a dose-related fashion and this effect is lessened over time. Although the isoflurane sparing effect of the 0.5 mg kg(-1) dose of methadone was smaller in comparison to the 1.0 mg kg(-1) dose, the lower dose is recommended for clinical use because it results in less evidence of cardiovascular impairment.en
dc.description.affiliationUniv Estadual Paulista, Fac Med Vet & Zootecnia, Dept Cirurgia & Anestesiol Vet, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Helsinki, Fac Vet Med, Dept Vet Clin Sci, Helsinki, Finland
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Bioestatist, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespDepartamento de Cirurgia e Anestesiologia Veterinária, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, SP, Brazil
dc.description.affiliationUnespDepartmento de Bioestatística, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent240-249
dc.identifierhttp://dx.doi.org/10.1111/j.1467-2995.2010.00528.x
dc.identifier.citationVeterinary Anaesthesia and Analgesia. Malden: Wiley-blackwell, v. 37, n. 3, p. 240-249, 2010.
dc.identifier.doi10.1111/j.1467-2995.2010.00528.x
dc.identifier.issn1467-2987
dc.identifier.orcid0000-0001-5478-4996
dc.identifier.urihttp://hdl.handle.net/11449/13589
dc.identifier.wosWOS:000276409300007
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofVeterinary Anaesthesia and Analgesia
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,800
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectisofluraneen
dc.subjectmethadoneen
dc.subjectminimum alveolar concentrationen
dc.titleEffects of methadone on the minimum alveolar concentration of isoflurane in dogsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes7162819131462797[4]
unesp.author.orcid0000-0001-6854-722X[4]
unesp.author.orcid0000-0001-5478-4996[6]
unesp.author.orcid0000-0002-3002-8093[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Cirurgia e Anestesiologia Veterinária - FMVZ
Artigos - Bioestatística - IBB