Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

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dc.contributor.authorStrakova, Andrea
dc.contributor.authorLeathlobhair, Máire Ní
dc.contributor.authorWang, Guo-Dong
dc.contributor.authorYin, Ting-Ting
dc.contributor.authorAirikkala-Otter, Ilona
dc.contributor.authorAllen, Janice L.
dc.contributor.authorAllum, Karen M.
dc.contributor.authorBansse-Issa, Leontine
dc.contributor.authorBisson, Jocelyn L.
dc.contributor.authorDomracheva, Artemio Castillo
dc.contributor.authorDe Castro, Karina F. [UNESP]
dc.contributor.authorCorrigan, Anne M.
dc.contributor.authorCran, Hugh R.
dc.contributor.authorCrawford, Jane T.
dc.contributor.authorCutter, Stephen M.
dc.contributor.authorKeenan, Laura Delgadillo
dc.contributor.authorDonelan, Edward M.
dc.contributor.authorFaramade, Ibikunle A.
dc.contributor.authorReynoso, Erika Flores
dc.contributor.authorFotopoulou, Eleni
dc.contributor.authorFruean, Skye N.
dc.contributor.authorGallardo-Arrieta, Fanny
dc.contributor.authorGlebova, Olga
dc.contributor.authorHäfelin Manrique, Rodrigo F.
dc.contributor.authorHenriques, Joaquim J. G. P.
dc.contributor.authorIgnatenko, Natalia
dc.contributor.authorKoenig, Debbie
dc.contributor.authorLanza-Perea, Marta
dc.contributor.authorLobetti, Remo
dc.contributor.authorLopezquintana, Adriana M.
dc.contributor.authorLosfelt, Thibault
dc.contributor.authorMarino, Gabriele
dc.contributor.authorMartincorena, Inigo
dc.contributor.authorCastañeda, Simón Martínez
dc.contributor.authorMartínez-López, Mayra F.
dc.contributor.authorMeyer, Michael
dc.contributor.authorNakanwagi, Berna
dc.contributor.authorDe Nardi, Andrigo B. [UNESP]
dc.contributor.authorNeunzig, Winifred
dc.contributor.authorNixon, Sally J.
dc.contributor.authorOnsare, Marsden M.
dc.contributor.authorOrtega-Pacheco, Antonio
dc.contributor.authorPeleteiro, Maria C.
dc.contributor.authorPye, Ruth J.
dc.contributor.authorReece, John F.
dc.contributor.authorGutierrez, Jose Rojas
dc.contributor.authorSadia, Haleema
dc.contributor.authorSchmeling, Sheila K.
dc.contributor.authorShamanova, Olga
dc.contributor.authorSsuna, Richard K.
dc.contributor.authorSteenland-Smitsvitich, Audrey E.Alla
dc.contributor.authorNgoka, Ismail Thoya
dc.contributor.authorVitǎlaru, Bogdan A.
dc.contributor.authorDe Vos, Anna P.
dc.contributor.authorDe Vos, Johan P.
dc.contributor.authorWalkinton, Oliver
dc.contributor.authorWedge, David C.
dc.contributor.authorWehrle-Martinez, Alvaro S.
dc.contributor.authorVan Der Wel, Mirjam G.
dc.contributor.authorWiddowson, Sophie Ae
dc.contributor.authorMurchison, Elizabeth P.
dc.contributor.institutionUniversity of Cambridge
dc.contributor.institutionChinese Academy of Sciences
dc.contributor.institutionWorldwide Veterinary Service
dc.contributor.institutionAnimal Management in Rural and Remote Indigenous Communities
dc.contributor.institutionWorld Vets
dc.contributor.institutionStichting Dierenbescherming Suriname
dc.contributor.institutionUniversity of Panama
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionSt. George’s University
dc.contributor.institutionThe Nakuru District Veterinary Scheme Ltd
dc.contributor.institutionAnimal Medical Centre
dc.contributor.institutionVeterinary clinic Sr. Dog’s
dc.contributor.institutionNational Veterinary Research Institute
dc.contributor.institutionInternational Fund for Animal Welfare
dc.contributor.institutionIntermunicipal Stray Animals Care Centre
dc.contributor.institutionAnimal Protection Society of Samoa
dc.contributor.institutionUniversity of Zulia
dc.contributor.institutionVeterinary clinic BIOCONTROL
dc.contributor.institutionVeterinary clinic El Roble
dc.contributor.institutionCentro Veterinário Berna
dc.contributor.institutionVeterinary clinic Zoovetservis
dc.contributor.institutionBryanston Veterinary Hospital
dc.contributor.institutionVeterinary Clinic Lopez Quintana
dc.contributor.institutionClinique Veterinaire de Grand Fond
dc.contributor.institutionUniversity of Messina
dc.contributor.institutionWellcome Trust Sanger Institute
dc.contributor.institutionMéxico
dc.contributor.institutionUniversidad de las Américas
dc.contributor.institutionTouray and Meyer Vet Clinic
dc.contributor.institutionThe Kampala Veterinary Surgery
dc.contributor.institutionVets Beyond Borders
dc.contributor.institutionAniworld veterinary clinic
dc.contributor.institutionAutonomous University of Yucatan
dc.contributor.institutionUniversity of Lisbon
dc.contributor.institutionHelp in Suffering
dc.contributor.institutionVeterinary clinic Dr José Rojas
dc.contributor.institutionUniversity of Veterinary and Animal Sciences
dc.contributor.institutionCorozal Veterinary Clinic
dc.contributor.institutionVeterinary clinic Vetmaster
dc.contributor.institutionLilongwe Society for Protection and Care of Animals
dc.contributor.institutionState Hospital of Veterinary Medicine
dc.contributor.institutionKenya Society for Protection and Care of Animals
dc.contributor.institutionClinical Sciences Department
dc.contributor.institutionLadybrand Animal Clinic
dc.contributor.institutionVeterinary Oncology Referral Centre De Ottenhorst
dc.contributor.institutionNational University of Asuncion
dc.contributor.institutionAnimal Anti Cruelty League
dc.date.accessioned2022-04-28T19:03:36Z
dc.date.available2022-04-28T19:03:36Z
dc.date.issued2016-05-17
dc.description.abstractCanine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.en
dc.description.affiliationDepartment of Veterinary Medicine University of Cambridge
dc.description.affiliationState Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic Animals Kunming Institute of Zoology Chinese Academy of Sciences
dc.description.affiliationInternational Training Center Worldwide Veterinary Service
dc.description.affiliationAnimal Management in Rural and Remote Indigenous Communities
dc.description.affiliationWorld Vets
dc.description.affiliationStichting Dierenbescherming Suriname
dc.description.affiliationCorozal Veterinary Hospital University of Panama
dc.description.affiliationDepartment of Clinical and Veterinary Surgery São Paulo State University
dc.description.affiliationSt. George’s University
dc.description.affiliationThe Nakuru District Veterinary Scheme Ltd
dc.description.affiliationAnimal Medical Centre
dc.description.affiliationVeterinary clinic Sr. Dog’s
dc.description.affiliationNational Veterinary Research Institute
dc.description.affiliationInternational Fund for Animal Welfare
dc.description.affiliationIntermunicipal Stray Animals Care Centre
dc.description.affiliationAnimal Protection Society of Samoa
dc.description.affiliationUniversity of Zulia
dc.description.affiliationVeterinary clinic BIOCONTROL
dc.description.affiliationVeterinary clinic El Roble
dc.description.affiliationOnevetGroup Centro Veterinário Berna
dc.description.affiliationVeterinary clinic Zoovetservis
dc.description.affiliationBryanston Veterinary Hospital
dc.description.affiliationVeterinary Clinic Lopez Quintana
dc.description.affiliationClinique Veterinaire de Grand Fond
dc.description.affiliationDepartment of Veterinary Sciences University of Messina
dc.description.affiliationWellcome Trust Sanger Institute
dc.description.affiliationUniversidad Autónoma del Estado de México
dc.description.affiliationSchool of Veterinary Medicine Universidad de las Américas
dc.description.affiliationTouray and Meyer Vet Clinic
dc.description.affiliationThe Kampala Veterinary Surgery
dc.description.affiliationVets Beyond Borders
dc.description.affiliationAniworld veterinary clinic
dc.description.affiliationAutonomous University of Yucatan
dc.description.affiliationInterdisciplinary Centre of Research in Animal Health University of Lisbon
dc.description.affiliationHelp in Suffering
dc.description.affiliationVeterinary clinic Dr José Rojas
dc.description.affiliationUniversity of Veterinary and Animal Sciences
dc.description.affiliationCorozal Veterinary Clinic
dc.description.affiliationVeterinary clinic Vetmaster
dc.description.affiliationLilongwe Society for Protection and Care of Animals
dc.description.affiliationState Hospital of Veterinary Medicine
dc.description.affiliationKenya Society for Protection and Care of Animals
dc.description.affiliationClinical Sciences Department
dc.description.affiliationLadybrand Animal Clinic
dc.description.affiliationVeterinary Oncology Referral Centre De Ottenhorst
dc.description.affiliationNational University of Asuncion
dc.description.affiliationAnimal Anti Cruelty League
dc.description.affiliationUnespDepartment of Clinical and Veterinary Surgery São Paulo State University
dc.description.sponsorshipLeverhulme Trust
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipRoyal Society
dc.description.sponsorshipIdWellcome Trust: 102942/Z/13/A
dc.description.sponsorshipIdRoyal Society: RG130615
dc.identifierhttp://dx.doi.org/10.7554/eLife.14552
dc.identifier.citationeLife, v. 5, n. MAY2016, 2016.
dc.identifier.doi10.7554/eLife.14552
dc.identifier.issn2050-084X
dc.identifier.scopus2-s2.0-84971672839
dc.identifier.urihttp://hdl.handle.net/11449/220627
dc.language.isoeng
dc.relation.ispartofeLife
dc.sourceScopus
dc.titleMitochondrial genetic diversity, selection and recombination in a canine transmissible canceren
dc.typeArtigo
unesp.author.orcid0000-0001-7462-8907[61]

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