Role of brain nitric oxide in the cardiovascular control of bullfrogs

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dc.contributor.authorZena, Lucas A. [UNESP]
dc.contributor.authorGargaglioni, Luciane H. [UNESP]
dc.contributor.authorBícego, Kênia C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionINCT-Fisiologia Comparada
dc.date.accessioned2014-05-27T11:29:34Z
dc.date.available2014-05-27T11:29:34Z
dc.date.issued2013-06-01
dc.description.abstractThe goal of the present study was to determine if nitric oxide (NO) acting on the brain of bullfrog (Lithobates catesbeianus) is involved in arterial pressure and heart rate (HR) control by influencing sympathetic activity. We investigated the effect of intracerebroventricular injections of l-NMMA (a nonselective NO synthase inhibitor) on mean arterial blood pressure (MAP), HR and cutaneous vascular conductance (CVC) of pelvic skin after intravenous injection of α or β adrenergic blockers, prazosin or sotalol, respectively. Arterial pressure was directly measured by a telemetry sensor inserted in the aortic arch of animals. l-NMMA increased MAP, but did not change HR. This hypertensive response was inhibited by the pre-treatment with prazosin, but accentuated by sotalol. The effect of l-NMMA on MAP was also inhibited by i.v. injections of the ganglionic blocker, hexamethonium. Thus, NO acting on the brain of bullfrog seems to present a hypotensive effect influencing the sympathetic activity dependent on α and β adrenergic receptors in the periphery. © 2013 Elsevier Inc.en
dc.description.affiliationDepartment of Animal Morphology and Physiology College of Agricultural and Veterinarian Sciences São Paulo State University, Jaboticabal, São Paulo 14884-900
dc.description.affiliationNational Inst. of Science and Technology on Comparative Physiology INCT-Fisiologia Comparada
dc.description.affiliationUnespDepartment of Animal Morphology and Physiology College of Agricultural and Veterinarian Sciences São Paulo State University, Jaboticabal, São Paulo 14884-900
dc.format.extent263-271
dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2013.03.020
dc.identifier.citationComparative Biochemistry and Physiology - A Molecular and Integrative Physiology, v. 165, n. 2, p. 263-271, 2013.
dc.identifier.doi10.1016/j.cbpa.2013.03.020
dc.identifier.file2-s2.0-84876345696.pdf
dc.identifier.issn1095-6433
dc.identifier.issn1531-4332
dc.identifier.scopus2-s2.0-84876345696
dc.identifier.urihttp://hdl.handle.net/11449/75508
dc.identifier.wosWOS:000319233300019
dc.language.isoeng
dc.relation.ispartofComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
dc.relation.ispartofjcr2.258
dc.relation.ispartofsjr0,836
dc.relation.ispartofsjr0,836
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAdrenergic receptors
dc.subjectL-NMMA
dc.subjectPrazosin
dc.subjectSotalol
dc.subjectTelemetry
dc.subjectalpha adrenergic receptor
dc.subjectbeta adrenergic receptor
dc.subjecthexamethonium
dc.subjectn(g) methylarginine
dc.subjectnitric oxide
dc.subjectprazosin
dc.subjectsotalol
dc.subjectaorta arch
dc.subjectarterial pressure
dc.subjectbody temperature
dc.subjectbrain
dc.subjectbullfrog
dc.subjectcardiovascular system
dc.subjectdiastolic blood pressure
dc.subjectheart rate
dc.subjectmean arterial pressure
dc.subjectnonhuman
dc.subjectskin blood vessel
dc.subjectsympathetic tone
dc.subjectsystolic blood pressure
dc.subjecttelemetry
dc.titleRole of brain nitric oxide in the cardiovascular control of bullfrogsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Morfologia e Fisiologia Animal - FCAV