Energy Expenditure and Oxygen Consumption as Novel Biomarkers of Obesity-induced Cardiac Disease in Rats

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dc.contributor.authorNovelli, Ethel L. B. [UNESP]
dc.contributor.authorSouza, Gisele A. [UNESP]
dc.contributor.authorEbaid, Geovana Xavier [UNESP]
dc.contributor.authorRocha, Katiucha K. H. R. [UNESP]
dc.contributor.authorSeiva, Fabio R. F. [UNESP]
dc.contributor.authorMani, Fernanda [UNESP]
dc.contributor.authorCampos, Kleber E.
dc.contributor.authorSforcin, Jose M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Fed Mato Grosso
dc.date.accessioned2014-05-20T15:32:24Z
dc.date.available2014-05-20T15:32:24Z
dc.date.issued2010-09-01
dc.description.abstractThe purpose of the present study was to determine calorimetric parameters to predict obesity adverse effects on oxidative stress and cardiac energy metabolism. Male Wistar 24 rats were divided into three groups (n = 8): given standard chow and water (C), receiving standard chow and 30% sucrose in its drinking water (S), and given sucrose-rich diet and water (SRD). After 45 days, both S and SRD rats had obesity, serum oxidative stress, and dyslipidemic profile, but the body weight gain and feed efficiency (FE) were higher in SRD than in S, whereas the obesity-related oxidative stress, myocardial triacylglycerol accumulation, and enhanced cardiac lactate dehydrogenase (LDH) activity were higher in S than in SRD rats. Myocardial beta-hydroxyacyl coenzyme-A-dehydrogenase was lower in SRD and in S than in C, whereas glycogen was only depleted in S rats. Myocardial pyruvate dehydrogenase (PDH) was lowest in S rats indicating depressed glucose oxidation. There was higher myocardial LDH/citrate synthase (CS) ratio and lower adenosine triphosphate (ATP)-synthetase indicating delayed aerobic metabolism in S rats than in the others. Cardiac ATP-synthetase was positively correlated with energy expenditure, namely resting metabolic rate (RMR), and with oxygen consumption per body weight (VO(2)/body weight). Myocardial lipid hydroperoxide (LH)/total antioxidant substances (TAS) ratio and triacylglycerol accumulation were negatively correlated with RMR and with VO(2)/body weight. In conclusion, the present study brought new insights into obesity because the study demonstrated for the first time that reduced energy expenditure and oxygen consumption may provide novel risk factors of obesity-induced reduced energy generation for myocardial contractile function. The results serve to highlight the role of calorimetric changes as novel biomarkers of risk to obesity-induced cardiac effects.en
dc.description.affiliationSão Paulo State Univ UNESP, Dept Chem & Biochem, Inst Biol Sci, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Sch Med, Dept Clin & Cardiol, São Paulo, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Inst Sci & Hlth, Dept Physiol, Sinop, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dept Immunol, Inst Biol Sci, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Chem & Biochem, Inst Biol Sci, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Med, Dept Clin & Cardiol, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Immunol, Inst Biol Sci, São Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1754-1761
dc.identifierhttp://dx.doi.org/10.1038/oby.2009.470
dc.identifier.citationObesity. New York: Nature Publishing Group, v. 18, n. 9, p. 1754-1761, 2010.
dc.identifier.doi10.1038/oby.2009.470
dc.identifier.issn1930-7381
dc.identifier.lattes5678783732311384
dc.identifier.orcid0000-0001-9137-7783
dc.identifier.urihttp://hdl.handle.net/11449/41320
dc.identifier.wosWOS:000281512400012
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofObesity
dc.relation.ispartofjcr4.042
dc.relation.ispartofsjr2,060
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleEnergy Expenditure and Oxygen Consumption as Novel Biomarkers of Obesity-induced Cardiac Disease in Ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderNature Publishing Group
unesp.author.lattes5678783732311384[6]
unesp.author.orcid0000-0001-9137-7783[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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