IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP

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dc.contributor.authorPiza, M. L. S. T. [UNESP]
dc.contributor.authorFeboli, A. [UNESP]
dc.contributor.authorAugusto, J. G. [UNESP]
dc.contributor.authorAnjos, L. A. [UNESP]
dc.contributor.authorLaurentiz, A. C. [UNESP]
dc.contributor.authorRoyo, V. A.
dc.contributor.authorAlvarenga, F. Q.
dc.contributor.authorLaurentiz, R. S. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Estadual Montes Claros
dc.date.accessioned2020-12-10T19:45:07Z
dc.date.available2020-12-10T19:45:07Z
dc.date.issued2019-01-01
dc.description.abstractGastrointestinal nematodes can affect sheep productivity via severe weight loss, anemia and death. Infection control is generally performed with synthetic anthelmintic compounds; however, indiscriminate use of these drugs can stimulate the emergence of resistant nematodes. Thus, alternatives to the use of synthetic anthelmintic compounds have been proposed, such as the inclusion of medicinal plants in animal feed. The objective of this study was evaluate the anthelmintic activity of the leaves of the medicinal plant Psidium cattleianum Sabine (Araca) through its hydroalcoholic extract, and using in vitro assays with the eggs and larvae of gastrointestinal nematodes obtained from naturally infected donor sheep. The extract exhibited good in vitro ovicidal and larvicidal activity, with IC50 values of 0.55 mg mL(-1) for egg hatching inhibition, 0.20 mg mL-1 for larval development inhibition and an efficiency greater than 80% in the inhibition of larval migration at all concentrations evaluated (IC50 < 0.19 mg/mL). Phytochemical analysis detected higher concentrations of saponins, flavonoids, cardiac glycosides, anthraquinones and tannins in the extract. Our results demonstrated that the Psidium cattleianum Sabine's leaves exhibit in vitro anthelmintic activity, which suggests that in addition to its other medicinal properties, this plant can help control gastrointestinal nematodes in sheep. Future in vivo assays should be performed to confirm antiparasitic efficacy.en
dc.description.affiliationUniv Estadual Paulista, FEIS, Dept Fis & Quim, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Biol & Zootecnia, FEIS, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Montes Claros, Campus Univ Prof Darcy Ribeiro, Montes Claros, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, FEIS, Dept Fis & Quim, Sao Paulo, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Biol & Zootecnia, FEIS, Sao Paulo, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/22096-7
dc.format.extent8
dc.identifierhttp://dx.doi.org/10.17523/bia.2019.v76.e1450
dc.identifier.citationBoletim De Industria Animal. Nova Odessa: Inst Zootecnia, v. 76, 8 p., 2019.
dc.identifier.doi10.17523/bia.2019.v76.e1450
dc.identifier.issn0067-9615
dc.identifier.urihttp://hdl.handle.net/11449/196442
dc.identifier.wosWOS:000504417900004
dc.language.isoeng
dc.publisherInst Zootecnia
dc.relation.ispartofBoletim De Industria Animal
dc.sourceWeb of Science
dc.subjectAraca
dc.subjectPhytotherapy
dc.subjectHaemonchus contortus
dc.titleIN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEPen
dc.typeArtigo
dcterms.rightsHolderInst Zootecnia

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Artigos - Física e Química - FEIS
Artigos - Biologia e Zootecnia - FEIS