Design and Characterization of Silicone and Surfactant Based Systems for Topical Drug Delivery

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dc.contributor.authorOyafuso, Marcia Helena [UNESP]
dc.contributor.authorCarvalho, Flavia Chiva [UNESP]
dc.contributor.authorChiavacci, Leila Aparecida [UNESP]
dc.contributor.authorGremião, Maria Palmira Daflon [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:55:44Z
dc.date.available2015-03-18T15:55:44Z
dc.date.issued2015-01-01
dc.description.abstractNanotechnology offers advantages for new drug delivery design by providing drug targeting while minimizing the side effects. Polyoxyethylene 20 cetyl alcohol (CETETH-20) is a surfactant that may form nanostructured systems, such as liquid crystals, when in contact with water/oil, which are structurally similar to biological membranes and may improve skin interaction. The aim of this study was to develop and characterize CETETH 20-based nanostructured systems by combining CETETH-20 with water and different oily phases, including PEG-12-dimethicone for topical drug administration. The systems were characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), rheology, texture profile analyses (TPA), in vitro cytotoxicity and histopathological analyses of rabbits' skin. Lamellar, hexagonal and cubic phases were identified and their viscoelastic moduli varied according to each phase. The stiffness of the cubic phase was 3-fold higher and twice more adhesive than the hexagonal phase. The formulations did not affect the normal macrophages cells, neither promoted skin irritation. They were spontaneously obtained by simply mixing the components, which corroborates for an ease scaled-up. These results suggest that systems composed of CETETH 20, PEG-12-dimethicone and water are a promising new approach for designing nanostructured topical drug delivery systems.en
dc.description.affiliationUniv Estadual Paulista UNESP, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPADC/FCF-UNESP
dc.format.extent817-826
dc.identifierhttp://dx.doi.org/10.1166/jnn.2015.9181
dc.identifier.citationJournal Of Nanoscience And Nanotechnology. Valencia: Amer Scientific Publishers, v. 15, n. 1, p. 817-826, 2015.
dc.identifier.doi10.1166/jnn.2015.9181
dc.identifier.issn1533-4880
dc.identifier.lattes9129780536724256
dc.identifier.lattes1427125996716282
dc.identifier.urihttp://hdl.handle.net/11449/117292
dc.identifier.wosWOS:000345054000147
dc.language.isoeng
dc.publisherAmer Scientific Publishers
dc.relation.ispartofJournal Of Nanoscience And Nanotechnology
dc.relation.ispartofjcr1.354
dc.relation.ispartofsjr0,326
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectNanotechnologyen
dc.subjectLiquid Crystalen
dc.subjectMicroemulsionen
dc.subjectOleic Aciden
dc.subjectMineral Oilen
dc.subjectPEG-12-Dimethiconeen
dc.subjectBrij (R)en
dc.subjectCeteth-20en
dc.titleDesign and Characterization of Silicone and Surfactant Based Systems for Topical Drug Deliveryen
dc.typeArtigo
dcterms.rightsHolderAmer Scientific Publishers
unesp.author.lattes9129780536724256
unesp.author.lattes1427125996716282
unesp.author.orcid0000-0002-6698-0545[5]
unesp.author.orcid0000-0001-7586-539X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR