Possible mechanism by which zinc protects the testicular function of rats exposed to cigarette smoke

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dc.contributor.authorSankako, Michele K. [UNESP]
dc.contributor.authorGarcia, Patricia C. [UNESP]
dc.contributor.authorPiffer, Renata C. [UNESP]
dc.contributor.authorDallaqua, Bruna [UNESP]
dc.contributor.authorDamasceno, Débora C. [UNESP]
dc.contributor.authorPereira, Oduvaldo C. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:27:23Z
dc.date.available2014-05-27T11:27:23Z
dc.date.issued2012-12-01
dc.description.abstractBackground: The aim of this study was to evaluate the changes in testicular function of rats due to cigarette smoke exposure and the possible mechanism by which zinc protects against these alterations. Methods: MaleWistar rats (60 days old) were randomly divided into 3 groups: control (G1, n = 10); exposed to cigarette smoke (G2, n = 10; 20 cigarettes/day/9 weeks) and exposed to cigarette smoke and supplemented with zinc (G3, n = 8; 20 cigarettes/day/9 weeks; 20 mg/kg zinc chloride daily for 9 weeks, by gavage). After the treatment period, the animals were euthanized, and materials were collected for analyses. Results: G2 rats showed a reduction in body mass; impaired sperm concentration, motility, morphology and vitality; and increased malonaldehyde and thiol group levels and superoxide dismutase activity as compared to G1. Zinc prevented the reduction of sperm concentration and the excessive increase of lipid peroxidation and induced an increase in plasma testosterone levels, wet weight of testis and thiol group concentration. Conclusions: Exposure to cigarette smoke led to harmful effects on testicular function at least partially due to the exacerbation of oxidative stress. Supplementary zinc had an important modulator/protector effect on certain parameters. The mechanism of zinc protection can be through an increase of SH concentration. Thus, zinc supplementation may be a promising addition to conventional treatments for male infertility related to smoking. Copyright © 2012 by Institute of Pharmacology Polish Academy of Sciences.en
dc.description.affiliationDepartment of Pharmacology Institute of Biosciences UNESP - Univ. Estadual Paulista, 18618-970 Botucatu, Sao Paulo
dc.description.affiliationDepartment of Gynecology and Obstetrics Botucatu Medical School UNESP - Univ. Estadual Paulista, 18618-970 Botucatu, Sao Paulo
dc.description.affiliationUnespDepartment of Pharmacology Institute of Biosciences UNESP - Univ. Estadual Paulista, 18618-970 Botucatu, Sao Paulo
dc.description.affiliationUnespDepartment of Gynecology and Obstetrics Botucatu Medical School UNESP - Univ. Estadual Paulista, 18618-970 Botucatu, Sao Paulo
dc.format.extent1537-1546
dc.identifierhttp://www.if-pan.krakow.pl/pjp/cont12.html#No6
dc.identifier.citationPharmacological Reports, v. 64, n. 6, p. 1537-1546, 2012.
dc.identifier.file2-s2.0-84874016167.pdf
dc.identifier.issn1734-1140
dc.identifier.scopus2-s2.0-84874016167
dc.identifier.urihttp://hdl.handle.net/11449/74001
dc.language.isoeng
dc.relation.ispartofPharmacological Reports
dc.relation.ispartofjcr2.787
dc.relation.ispartofsjr0,773
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectOxidative stress
dc.subjectRats
dc.subjectSemen
dc.subjectSmoking
dc.subjectSpermatozoa
dc.subjectTestis
dc.subjectZinc
dc.subjectcigarette smoke
dc.subjectlipid
dc.subjectmalonaldehyde
dc.subjectsuperoxide dismutase
dc.subjecttestosterone
dc.subjectthiol group
dc.subjectzinc chloride
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcell structure
dc.subjectcontrolled study
dc.subjectdrug mechanism
dc.subjectenvironmental exposure
dc.subjectenzyme activity
dc.subjectenzyme blood level
dc.subjecthistopathology
dc.subjecthormone determination
dc.subjectlipid peroxidation
dc.subjectmale
dc.subjectmolecular mechanics
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectprotein blood level
dc.subjectrat
dc.subjectsemen analysis
dc.subjectspermatozoon abnormality
dc.subjectspermatozoon density
dc.subjectspermatozoon motility
dc.subjecttestis function
dc.subjecttestis weight
dc.subjecttestosterone blood level
dc.subjecttreatment duration
dc.subjecttreatment response
dc.subjectvitamin supplementation
dc.titlePossible mechanism by which zinc protects the testicular function of rats exposed to cigarette smokeen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Farmacologia - IBB
Artigos - Ginecologia e Obstetrícia - FMB