Autoimmunity does not contribute to the highly prevalent glucose metabolism disturbances in a Japanese Brazilian population

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dc.contributor.authorHashimoto, Silvia M.
dc.contributor.authorHirai, A. T.
dc.contributor.authorKikuchi, M.
dc.contributor.authorCardoso, M. A. [UNESP]
dc.contributor.authorTomita, N.
dc.contributor.authorChaim, R.
dc.contributor.authorWakisaka, K.
dc.contributor.authorGimeno, Suely G.A.
dc.contributor.authorMatsumura, Luiza
dc.contributor.authorFranco, Laercio J.
dc.contributor.authorMiranda, Walkiria L.
dc.contributor.authorFerreira, Sandra R.G.
dc.contributor.authorOsiro, K.
dc.contributor.authorIunes, M.
dc.contributor.authorDe Barros Junior, Newton
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Sagrado Coração (USC)
dc.contributor.institutionJapanese Brazilian Study Center
dc.date.accessioned2014-05-27T11:22:44Z
dc.date.available2014-05-27T11:22:44Z
dc.date.issued2007-12-01
dc.description.abstractThe Japanese Brazilian population has one of the highest prevalences of diabetes worldwide. Despite being non-obese according to standard definitions, their body fat distribution is typically central. We investigated whether a subset of these subjects had autoantibodies that would suggest a slowly progressive form of type 1 diabetes. A total of 721 Japanese Brazilians (386 men) in the 30- to 60-year age group underwent clinical examination and laboratory procedures, including a 75-g oral glucose tolerance test and determinations of serum autoantibodies. Antibodies to glutamic acid decarboxylase (GADab) were determined by radioimmunoassay and to thyroglobulin (TGab) and thyroperoxidase (TPOab) by flow-cytometry assays. Mean body mass index was 25.2 ± 3.8 kg/m2, but waist circumference was elevated according to the Asian standards. Diabetes, impaired glucose tolerance, and impaired fasting glycemia were found in 31%, 22%, and 22%, respectively, and 53% of the subjects had metabolic syndrome. Glutamic acid decarboxylase (GADab) was positive in 4.72%, TGab in 9.6%, and TPOab in 10% of the whole sample. When participants were stratified according to the presence of thyroid antibodies, similar frequencies of GADab were found in positive and negative groups. The prevalence rates of glucose metabolism disturbances did not differ between GADab positive and negative groups. Our data did not support the view that autoimmune injury could contribute to the high prevalence of diabetes seen in Japanese Brazilians, and the presence of co-morbidities included in the spectrum of metabolic syndrome favors the classification as type 2 diabetes.en
dc.description.affiliationInternal Medicine Department Endocrinology Division Federal University of São Paulo, São Paulo, SP
dc.description.affiliationPreventive Medicine Department Federal University of São Paulo, São Paulo, SP
dc.description.affiliation, Rua Aimberé n 909 apt. 104, 05018-011 São Paulo
dc.description.affiliationSurgery Dept. Federal University of Sao Paulo, Sao Paulo
dc.description.affiliationProgram in Clinical Endocrinology Federal University of Sao Paulo, Sao Paulo
dc.description.affiliationPreventive Medicine Department Medicine School of Ribeirao, Preto
dc.description.affiliationSao Paulo University, Sao Paulo
dc.description.affiliationEpidemiology and Public Health Dept. Sao Paulo State University, Sao Paulo
dc.description.affiliationDental School Sao Paulo University, Bauru
dc.description.affiliationNutrition School Sagrado Coraçao University, Bauru, SP
dc.description.affiliationJapanese Brazilian Study Center, Sao Paulo
dc.description.affiliationUnespEpidemiology and Public Health Dept. Sao Paulo State University, Sao Paulo
dc.format.extent78-83
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17274214
dc.identifier.citationEthnicity and Disease, v. 17, n. 1, p. 78-83, 2007.
dc.identifier.issn1049-510X
dc.identifier.scopus2-s2.0-33846931400
dc.identifier.urihttp://hdl.handle.net/11449/70170
dc.language.isoeng
dc.relation.ispartofEthnicity and Disease
dc.relation.ispartofjcr1.053
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectDiabetes
dc.subjectGlutamic acid decarboxylase antibodies
dc.subjectJapanese migrants
dc.subjectMetabolic syndrome
dc.subjectThyroid antibodies
dc.subjectglucose
dc.subjectglutamate decarboxylase antibody
dc.subjectthyroglobulin antibody
dc.subjectthyroid antibody
dc.subjectthyroid peroxidase antibody
dc.subjectadult
dc.subjectantibody blood level
dc.subjectAsian
dc.subjectautoimmunity
dc.subjectbody mass
dc.subjectBrazil
dc.subjectclinical examination
dc.subjectcomorbidity
dc.subjectcontrolled study
dc.subjectdiabetogenesis
dc.subjectfemale
dc.subjectflow cytometry
dc.subjectglucose metabolism
dc.subjecthuman
dc.subjectimmunopathogenesis
dc.subjectimpaired glucose tolerance
dc.subjectinsulin dependent diabetes mellitus
dc.subjectJapan
dc.subjectlaboratory test
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmetabolic syndrome X
dc.subjectoral glucose tolerance test
dc.subjectprevalence
dc.subjectradioimmunoassay
dc.subjectwaist circumference
dc.subjectAdult
dc.subjectAutoantibodies
dc.subjectAutoimmunity
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectFlow Cytometry
dc.subjectGlutamate Decarboxylase
dc.subjectHumans
dc.subjectIodide Peroxidase
dc.subjectMale
dc.subjectMetabolic Syndrome X
dc.subjectMiddle Aged
dc.subjectPrevalence
dc.subjectRadioimmunoassay
dc.subjectROC Curve
dc.subjectSeroepidemiologic Studies
dc.subjectThyroglobulin
dc.subjectThyroid Gland
dc.titleAutoimmunity does not contribute to the highly prevalent glucose metabolism disturbances in a Japanese Brazilian populationen
dc.typeArtigo
dcterms.licensehttp://www.ishib.org/wordpress/?page_id=595

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