Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis

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dc.contributor.authorNascimento, ALTO
dc.contributor.authorKo, A. I.
dc.contributor.authorMartins, EAL
dc.contributor.authorMonteiro-Vitorello, C. B.
dc.contributor.authorHo, P. L.
dc.contributor.authorHaake, D. A.
dc.contributor.authorVerjovski-Almeida, S.
dc.contributor.authorHartskeerl, R. A.
dc.contributor.authorMarques, M. V.
dc.contributor.authorOliveira, M. C.
dc.contributor.authorMenck, CFM
dc.contributor.authorLeite, LCC
dc.contributor.authorCarrer, H.
dc.contributor.authorCoutinho, L. L.
dc.contributor.authorDegrave, W. M.
dc.contributor.authorDellagostin, O. A.
dc.contributor.authorEl-Dorry, H.
dc.contributor.authorFerro, E. S.
dc.contributor.authorFerro, MIT
dc.contributor.authorFurlan, L. R.
dc.contributor.authorGamberini, M.
dc.contributor.authorGiglioti, E. A.
dc.contributor.authorGoes-Neto, A.
dc.contributor.authorGoldman, G. H.
dc.contributor.authorGoldman, MHS
dc.contributor.authorHarakava, R.
dc.contributor.authorJeronimo, SMB
dc.contributor.authorJunqueira-de-Azevedo, ILM
dc.contributor.authorKimura, E. T.
dc.contributor.authorKuramae, E. E.
dc.contributor.authorLemos, EGM
dc.contributor.authorLemos, MVF
dc.contributor.authorMarino, C. L.
dc.contributor.authorNunes, L. R.
dc.contributor.authorde Oliveira, R. C.
dc.contributor.authorPereira, G. G.
dc.contributor.authorReis, M. S.
dc.contributor.authorSchriefer, A.
dc.contributor.authorSiqueira, W. J.
dc.contributor.authorSommer, P.
dc.contributor.authorTsai, S. M.
dc.contributor.authorSimpson, AJG
dc.contributor.authorFerro, J. A.
dc.contributor.authorCamargo, LEA
dc.contributor.authorKitajima, J. P.
dc.contributor.authorSetubal, J. C.
dc.contributor.authorVan Sluys, M. A.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionFac Ciências Farmaceut
dc.contributor.institutionFac Filosofia Ciências & Letras
dc.contributor.institutionUniv Mogi Cruzes
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionUniversidade Estadual de Feira de Santana (UEFS)
dc.contributor.institutionInst Oswaldo Cruz
dc.contributor.institutionUniversidade Federal de Pelotas (UFPEL)
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)
dc.contributor.institutionCornell Univ
dc.contributor.institutionLudwig Inst Canc Res
dc.contributor.institutionUniv Calif Los Angeles
dc.contributor.institutionVet Affairs Greater Los Angeles Healthcare Syst
dc.contributor.institutionKoninklin Inst Tropen
dc.date.accessioned2014-05-20T15:29:48Z
dc.date.available2014-05-20T15:29:48Z
dc.date.issued2004-04-01
dc.description.abstractLeptospira species colonize a significant proportion of rodent populations worldwide and produce life-threatening infections in accidental hosts, including humans. Complete genome sequencing of Leptospira interrogans serovar Copenhageni and comparative analysis with the available Leptospira interrogans serovar Lai genome reveal that despite overall genetic similarity there are significant structural differences, including a large chromosomal inversion and extensive variation in the number and distribution of insertion sequence elements. Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis. A broad array of transcriptional regulation proteins and two new families of afimbrial adhesins which contribute to host tissue colonization in the early steps of infection were identified. Differences in genes involved in the biosynthesis of lipopolysaccharide 0 side chains between the Copenhageni and Lai serovars were identified, offering an important starting point for the elucidation of the organism's complex polysaccharide surface antigens. Differences in adhesins and in lipopolysaccharide might be associated with the adaptation of serovars Copenhageni and Lai to different animal hosts. Hundreds of genes encoding surface-exposed lipoproteins and transmembrane outer membrane proteins were identified as candidates for development of vaccines for the prevention of leptospirosis.en
dc.description.affiliationUniv São Paulo, Ctr Biotechnol, Inst Butantan, BR-05503900 São Paulo, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Ciências Biomed, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biociencias, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Piracicaba, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Agrarias & Vet, Jaboticabal, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Ctr Ciências Agrarias, Araras, Brazil
dc.description.affiliationFac Ciências Farmaceut, Ribeirao Preto, Brazil
dc.description.affiliationFac Filosofia Ciências & Letras, Ribeirao Preto, Brazil
dc.description.affiliationUniv São Paulo, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUniv Mogi Cruzes, Fac Ciências Agron, Mogi Cruzes, Brazil
dc.description.affiliationUniv Mogi Cruzes, Inst Biociencias, Mogi Cruzes, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu, SP, Brazil
dc.description.affiliationUniv Mogi Cruzes, Nucleo Integrado Biotecnol, Mogi Das Cruzes, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Genet & Evolucao, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Computacao, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Agron Campinas, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Ctr Biol Mol & Engn Genet, Campinas, SP, Brazil
dc.description.affiliationUniv Fed Bahia, Serv Immunol, BR-41170290 Salvador, BA, Brazil
dc.description.affiliationUEFS, LAPEM, Dept Ciências Biol, Feira de Santana, BA, Brazil
dc.description.affiliationInst Oswaldo Cruz, Dept Bioquim & Biol Mol, BR-20001 Rio de Janeiro, Brazil
dc.description.affiliationUniv Fed Pelotas, Ctr Biotechnol, Pelotas, Brazil
dc.description.affiliationUniv Fed Rio Grande Norte, Ctr Biociencias, BR-59072970 Natal, RN, Brazil
dc.description.affiliationCornell Univ, Weill Med Coll, Div Int Med & Infect Dis, New York, NY USA
dc.description.affiliationLudwig Inst Canc Res, New York, NY USA
dc.description.affiliationUniv Calif Los Angeles, Sch Med, Los Angeles, CA USA
dc.description.affiliationVet Affairs Greater Los Angeles Healthcare Syst, Div Infect Dis, Los Angeles, CA USA
dc.description.affiliationKoninklin Inst Tropen, Royal Trop Inst, KIT Biomed Res, Amsterdam, Netherlands
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Agrarias & Vet, Jaboticabal, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Genet & Evolucao, Campinas, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Computacao, Campinas, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Agron Campinas, Campinas, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Ctr Biol Mol & Engn Genet, Campinas, SP, Brazil
dc.format.extent2164-2172
dc.identifierhttp://dx.doi.org/10.1128/JB.186.7.2164-2172.2004
dc.identifier.citationJournal of Bacteriology. Washington: Amer Soc Microbiology, v. 186, n. 7, p. 2164-2172, 2004.
dc.identifier.doi10.1128/JB.186.7.2164-2172.2004
dc.identifier.fileWOS000220363200029.pdf
dc.identifier.issn0021-9193
dc.identifier.lattes7179273060624761
dc.identifier.lattes0147241723612464
dc.identifier.lattes0165348738208319
dc.identifier.orcid0000-0003-4524-954X
dc.identifier.urihttp://hdl.handle.net/11449/39301
dc.identifier.wosWOS:000220363200029
dc.language.isoeng
dc.publisherAmer Soc Microbiology
dc.relation.ispartofJournal of Bacteriology
dc.relation.ispartofjcr3.219
dc.relation.ispartofsjr1,885
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleComparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesisen
dc.typeArtigo
dcterms.licensehttp://journals.asm.org/site/misc/ASM_Author_Statement.xhtml
dcterms.rightsHolderAmer Soc Microbiology
unesp.author.lattes7179273060624761
unesp.author.lattes0147241723612464
unesp.author.lattes0165348738208319[33]
unesp.author.orcid0000-0002-6506-2734[47]
unesp.author.orcid0000-0002-4784-9904[27]
unesp.author.orcid0000-0002-7692-6243[23]
unesp.author.orcid0000-0002-7266-8881[14]
unesp.author.orcid0000-0002-1238-9354[4]
unesp.author.orcid0000-0001-8495-2962[10]
unesp.author.orcid0000-0001-9619-269X[34]
unesp.author.orcid0000-0002-3733-6312[41]
unesp.author.orcid0000-0003-2803-4088[16]
unesp.author.orcid0000-0002-3966-1303[43]
unesp.author.orcid0000-0002-2986-350X[25]
unesp.author.orcid0000-0002-3754-9115[37]
unesp.author.orcid0000-0002-9329-1841[13]
unesp.author.orcid0000-0003-1651-9192[43]
unesp.author.orcid0000-0003-0156-1312[12]
unesp.author.orcid0000-0003-4851-0870[1]
unesp.author.orcid0000-0001-9023-2339[2]
unesp.author.orcid0000-0002-2446-5510[301]
unesp.author.orcid0000-0001-8403-4459[29]
unesp.author.orcid0000-0001-6701-8668[30]
unesp.author.orcid0000-0002-2333-9379[3]
unesp.author.orcid0000-0002-5650-5695[44]
unesp.author.orcid0000-0003-1941-0694[11]
unesp.author.orcid0000-0001-9174-2816[46]
unesp.author.orcid0000-0003-3652-241X[5]
unesp.author.orcid0000-0002-6356-2401[7]
unesp.author.orcid0000-0003-1431-2665[26]
unesp.author.orcid0000-0002-6786-9320[25]
unesp.author.orcid0000-0003-4524-954X[33]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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