Replication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymer

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dc.contributor.authorElkaseer, Ahmed
dc.contributor.authorMueller, Tobias
dc.contributor.authorAzcarate, Sabino
dc.contributor.authorPhilipp-Pichler, Martin
dc.contributor.authorWilfinger, Thomas
dc.contributor.authorWittner, Wolfgang
dc.contributor.authorPrantl, Manfred
dc.contributor.authorSampaio, Daniel [UNESP]
dc.contributor.authorHagenmeyer, Veit
dc.contributor.authorScholz, Steffen
dc.contributor.institutionKarlsruhe Institute of Technology
dc.contributor.institutionPort Said University
dc.contributor.institutionIK4-TEKNIKER
dc.contributor.institutionWittmann Battenfeld GmbH
dc.contributor.institutionRHP Technology GmbH
dc.contributor.institutionErnst Wittner Ges. m. b. H.
dc.contributor.institutionAlicona Imaging GmbH
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:54:06Z
dc.date.available2018-12-11T16:54:06Z
dc.date.issued2018-06-26
dc.description.abstractThe present paper reports on the development of a biodegradable overmolded orthopedic implant: a metal bone fixing screw, which has been overmolded with a functionalized thin layer of biodegradable polymer to enhance cell adhesion during the healing process. The main challenges were to integrate precise, high-throughput and repeatable solutions to achieve a thin, defect-free structured polymer layer and to ensure a high and consistent implant quality. The work carried out entailed determining proper materials (Purasorb PDLG 5010) for the biodegradable overmolding layer and its economical substitute (NaKu PLA 100HF) to be used during initial tool and process development, designing the surface structure of the overmolded polymer layer, development of injection molding tools, as well as feeding and handling procedures. The injection overmolding process of Purasorb PDLG 5010 polymer was controlled, and the process parameters were optimized. In particular, the dominant process parameters for the overmolding, namely injection pressure, barrel temperature and mold temperature, were experimentally examined using a circumscribed three-factor central composite design and two quality marks; overmolding roughness and mass of polymer. The analysis of the experimental results shows that the mass of the overmolding is not feasible for use as the quality mark. However, the optimal parameters for the overmolding of a metallic implant screw with a thin, micro-structured polymer layer with a predefined roughness of the surface texture have been identified successfully.en
dc.description.affiliationInstitute for Automation and Applied Informatics Karlsruhe Institute of Technology
dc.description.affiliationFaculty of Engineering Port Said University
dc.description.affiliationIK4-TEKNIKER, c/Iñaki Goenaga 5
dc.description.affiliationWittmann Battenfeld GmbH
dc.description.affiliationRHP Technology GmbH
dc.description.affiliationErnst Wittner Ges. m. b. H.
dc.description.affiliationAlicona Imaging GmbH
dc.description.affiliationFaculdade de Engenharia Universidade Estadual Paulista (Unesp)
dc.description.affiliationUnespFaculdade de Engenharia Universidade Estadual Paulista (Unesp)
dc.identifierhttp://dx.doi.org/10.3390/polym10070707
dc.identifier.citationPolymers, v. 10, n. 7, 2018.
dc.identifier.doi10.3390/polym10070707
dc.identifier.file2-s2.0-85049157425.pdf
dc.identifier.issn2073-4360
dc.identifier.scopus2-s2.0-85049157425
dc.identifier.urihttp://hdl.handle.net/11449/171148
dc.language.isoeng
dc.relation.ispartofPolymers
dc.relation.ispartofsjr0,852
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBiodegradable polymer
dc.subjectFunctionalized surface
dc.subjectMicro injection molding
dc.subjectOrthopedic implants
dc.subjectProcess optimization
dc.titleReplication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymeren
dc.typeArtigo

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