Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity

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dc.contributor.authorHiguchi, Célio Takashi [UNESP]
dc.contributor.authorSannomiya, M. [UNESP]
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorLeite, S. R. A. [UNESP]
dc.contributor.authorSato, D. N.
dc.contributor.authorFranzblau, S. G.
dc.contributor.authorSacramento, Luis Vitor Silva do [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Adolfo
dc.contributor.institutionUniv Illinois
dc.date.accessioned2014-05-20T13:24:18Z
dc.date.available2014-05-20T13:24:18Z
dc.date.issued2011-01-01
dc.description.abstractBioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 mu g mL(-1)), triterpenoids as bassic acid (MIC = 2.5 mu g mL(-1)), alpha-amyrin acetate (MIC = 62.5 mu g mL(-1)), a mixture of lupeol, alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)) and a mixture of lupeol, and acetates of alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK).en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Unesp, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Unesp, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationInst Adolfo, Lab Micobacteriol, BR-14085410 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Illinois, Coll Pharm, Inst TB Res, Chicago, IL USA
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Unesp, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Unesp, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 02/05503-6
dc.format.extent5
dc.identifierhttp://dx.doi.org/10.1093/ecam/nen077
dc.identifier.citationEvidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 5, 2011.
dc.identifier.doi10.1093/ecam/nen077
dc.identifier.fileWOS000293355700001.pdf
dc.identifier.issn1741-427X
dc.identifier.lattes7927877224326837
dc.identifier.lattes1493338692663672
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/7499
dc.identifier.wosWOS:000293355700001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine
dc.relation.ispartofjcr2.064
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleByrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activityen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/apm/apc/
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes7927877224326837
unesp.author.lattes1493338692663672
unesp.author.orcid0000-0002-6969-3963[3]
unesp.author.orcid0000-0003-3306-9170[2]
unesp.author.orcid0000-0002-8698-0243[6]
unesp.author.orcid0000-0003-3032-2556[8]
unesp.author.orcid0000-0003-0433-2910[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicentept
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Ciências Biológicas - São Vicente
Artigos - Ciências Biológicas - FCFAR