Periosteum-Derived Cells as an Alternative to Bone Marrow Cells for Bone Tissue Engineering Around Dental Implants. A Histomorphometric Study in Beagle Dogs

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dc.contributor.authorRibeiro, Fernanda V.
dc.contributor.authorSuaid, Fabricia F.
dc.contributor.authorRuiz, Karina G. S.
dc.contributor.authorSalmon, Cristiane R.
dc.contributor.authorPaparotto, Telma [UNESP]
dc.contributor.authorNociti, Francisco H.
dc.contributor.authorSallum, Enilson A.
dc.contributor.authorCasati, Marcio Z.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:30:30Z
dc.date.available2014-05-20T15:30:30Z
dc.date.issued2010-06-01
dc.description.abstractBackground: The aim of this study is to investigate the potential use of periosteum-derived cells (PCs) for tissue engineering in pen-implant defects.Methods: Bone marrow cells (BMCs) and PCs were harvested from seven adult beagle dogs, cultured in vitro, and phenotypically characterized with regard to their osteogenic properties. The animals were then subjected to teeth extraction, and 3 months later, two implant sites were drilled, bone dehiscences created, and dental implants placed. Dehiscences were randomly assigned to one of two groups: PCs (PCs + carrier) and BMCs (BMCs + carrier). After 3 months, the animals were sacrificed and the implants with adjacent hard tissues were processed for undecalcified sections. Bone-to-implant contact, bone fill within the limits of implant threads, and new bone area in a zone lateral to the implant were histometrically obtained.Results: In vitro, phenotypic characterization demonstrated that both cell populations presented osteogenic potential, as identified by the mineral nodule formation and the expression of bone markers. Histometrically, an intergroup analysis showed that both cell-treated defects had similar bone fill within the limits of implant threads and bone-to-implant contact (P>0.05), and although a trend toward higher new bone area values was found for the PC group, there was no significant difference between the experimental groups (P>0.05).Conclusions: Periosteal and bone marrow cells presented a similar potential for bone reconstruction. As such, periosteum may be considered as an alternative source of osteogenic cells in implant dentistry. J Periodontol 2010;81:907-916.en
dc.description.affiliationUniv Estadual Campinas, Sch Dent Piracicaba, Dept Prosthodont & Periodont, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Sch Vet Med & Anim Sci, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Vet Med & Anim Sci, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/55596-4
dc.description.sponsorshipIdFAPESP: 06/59431-7
dc.format.extent907-916
dc.identifierhttp://dx.doi.org/10.1902/jop.2010.090604
dc.identifier.citationJournal of Periodontology. Chicago: Amer Acad Periodontology, v. 81, n. 6, p. 907-916, 2010.
dc.identifier.doi10.1902/jop.2010.090604
dc.identifier.issn0022-3492
dc.identifier.urihttp://hdl.handle.net/11449/39860
dc.identifier.wosWOS:000283021200014
dc.language.isoeng
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal of Periodontology
dc.relation.ispartofjcr3.392
dc.relation.ispartofsjr1,408
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBone marrowen
dc.subjectbone regenerationen
dc.subjectdental implantsen
dc.subjectperiosteumen
dc.subjecttissue engineeringen
dc.titlePeriosteum-Derived Cells as an Alternative to Bone Marrow Cells for Bone Tissue Engineering Around Dental Implants. A Histomorphometric Study in Beagle Dogsen
dc.typeArtigo
dcterms.licensehttp://www.joponline.org/page/permissionRequests.jsp
dcterms.rightsHolderAmer Acad Periodontology

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