Role of Locus coeruleus noradrenergic neurons in cardiorespiratory and thermal control during hypoxia

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dc.contributor.authorBiancardi, Vivian [UNESP]
dc.contributor.authorda Silva, Luana Tenorio [UNESP]
dc.contributor.authorBicego, Kenia C. [UNESP]
dc.contributor.authorGargaglioni, Luciane H. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:15:40Z
dc.date.available2014-05-20T13:15:40Z
dc.date.issued2010-02-28
dc.description.abstractWe investigated the specific role of LC noradrenergic (NA) neurons in the cardiorespiratory and thermal responses to hypoxia. Aiming this, LC NA neurons were selectively destroyed by microinjecting 6-OHDA bilaterally in the LC of male rats. Pulmonarl ventilation ((V) over dotE, plethysmograph), core body temperature (Tc, dataloggers), mean arterial pressure (MAP) and heart rate (fH) were measured during normoxia followed by 7% O(2) in air. Tyrosine hydroxylase (TH) immunoreactivity was performed to verify the chemical lesions effectiveness. Hypoxia caused increase in (V) over dotE, decrease in Tc and did not affect fH in both sham-operated and 6-OHDA-lesioned groups. In addition, hypoxia decreased MAP in the sham-operated group and did not affect MAP in the 6-OHDA-lesioned group. LC lesion did not affect (V) over dotE, MAP, fH and Tc. Thus, these results indicate that LC noradrenergic neurons do not play a role in cardiorespiratory control and thermoregulation under basal and hypoxic conditions. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Dept Anim Morphol & Physiol, FCAV Jaboticabal, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Anim Morphol & Physiol, FCAV Jaboticabal, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipInstituto Nacional de Ciência e Tecnologia em Fisiologia Comparada (INCT)
dc.format.extent150-156
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2009.12.004
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 170, n. 2, p. 150-156, 2010.
dc.identifier.doi10.1016/j.resp.2009.12.004
dc.identifier.issn1569-9048
dc.identifier.urihttp://hdl.handle.net/11449/2755
dc.identifier.wosWOS:000275259400003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.relation.ispartofjcr1.792
dc.relation.ispartofsjr0,682
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAnapyrexiaen
dc.subjectNoradrenalineen
dc.subject6-Hydroxydopamineen
dc.titleRole of Locus coeruleus noradrenergic neurons in cardiorespiratory and thermal control during hypoxiaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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