Matemal separation affects cocaine-induced locomotion and response to novelty in adolescent, but not in adult rats

Página do item simplificado
dc.contributor.authorMarin, Marcelo Tadeu [UNESP]
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:27Z
dc.date.available2014-05-20T13:24:27Z
dc.date.issued2004-07-02
dc.description.abstractMaternal separation is known to exert long-term effects on both behavior and the neuroendocrine system. We investigated cocaine-induced locomotor activation as well as the locomotor and corticosterone response to forced novelty in maternally separated adolescent and adult rats. Maternal separation consisted of separating litters from their darns daily during 5 h from postnatal days 2 to 6. Control animals were subjected only to regular cage changes. Cocaine- (10 mg/kg, i.p.) and novelty-induced locomotion were recorded in an activity cage. After the animals were tested for behavioral response to novelty, trunk blood samples were collected and plasma corticosterone levels were determined by radioimmunoassay. Adolescent rats exposed to maternal separation exhibited an increased locomotor response to novelty and cocaine; corticosterone levels were lower in these adolescent animals, after exposure to the novel environment. These effects of materrial separation were not observed in rats that were tested as adults. Thus the maternal separation protocol produced enduring but transient changes in the behavioral response to cocaine and in the stress response to novelty. (C) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.format.extent83-90
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2004.04.003
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1013, n. 1, p. 83-90, 2004.
dc.identifier.doi10.1016/j.brainres.2004.04.003
dc.identifier.issn0006-8993
dc.identifier.lattes2514762545280942
dc.identifier.lattes7920438802539727
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/7586
dc.identifier.wosWOS:000222726300008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmaternal separationpt
dc.subjectcocainept
dc.subjectcorticosteronept
dc.subjectnoveltypt
dc.subjectadolescencept
dc.subjectearly stresspt
dc.titleMatemal separation affects cocaine-induced locomotion and response to novelty in adolescent, but not in adult ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7920438802539727
unesp.author.lattes2514762545280942[2]
unesp.author.orcid0000-0002-0522-2839[1]
unesp.author.orcid0000-0002-1378-6327[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR