Echocardiographic detection of congestive heart failure in postinfarction rats

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dc.contributor.authorMartinez, Paula F. [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.authorOliveira, Silvio A. [UNESP]
dc.contributor.authorCampos, Dijon H. S. [UNESP]
dc.contributor.authorLima, Aline R. R. [UNESP]
dc.contributor.authorDamatto, Ricardo L. [UNESP]
dc.contributor.authorCezar, Marcelo D. M. [UNESP]
dc.contributor.authorBonomo, Camila [UNESP]
dc.contributor.authorGuizoni, Daniele M. [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.authorOkoshi, Marina Politi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.date.accessioned2014-05-20T13:48:01Z
dc.date.available2014-05-20T13:48:01Z
dc.date.issued2011-08-01
dc.description.abstractMartinez PF, Okoshi K, Zornoff LA, Oliveira Jr SA, Campos DH, Lima AR, Damatto RL, Cezar MD, Bonomo C, Guizoni DM, Padovani CR, Cicogna AC, Okoshi MP. Echocardiographic detection of congestive heart failure in postinfarction rats. J Appl Physiol 111: 543-551, 2011. First published May 26, 2011; doi:10.1152/japplphysiol.01154.2010.-In studies of congestive heart failure (CHF) treatment, it is essential to select animals with a similar degree of cardiac dysfunction. However, this is difficult to establish without hemodynamic evaluation in rat postinfarction-induced CHF. This study aimed to diagnose CHF in long-term follow-up postinfarction rats using only echocardiographic criteria through a J-tree cluster analysis and Fisher's linear discriminant function. Two sets of sham and infarcted rats were studied. The first was used to perform cluster analysis and the second to prospectively validate the results. Six months after inducing myocardial infarction (MI), rats were subjected to transthoracic echocardiography. Infarct size was measured by histological analysis. Six echocardiographic variables were used in the cluster analysis: left ventricular (LV) systolic dimension, LV diastolic dimension-to-body weight ratio, left atrial diameter-to-body weight ratio, LV posterior wall shortening velocity, E wave, and isovolumetric relaxation time. Cluster analysis joined the rats into one sham and two MI groups. One MI cluster had more severe anatomical and echocardiographic changes and was called MI with heart failure (MI/HF+, n = 24, infarct size: 42.7 +/- 5.8%). The other had less severe changes and was called MI without heart failure (MI/HF-, n = 11, infarct size: 32.3 +/- 9.9%; P < 0.001 vs. MI/HF+). Three rats with small infarct size (21.6 +/- 2.2%) presenting mild cardiac alterations were misallocated in the sham group. Fisher's linear discriminant function was built using these groups and used to prospectively classify additional groups of sham-operated (n = 20) and infarcted rats (n = 57) using the same echocardiographic parameters. The discriminant function therefore detected CHF with 100% specificity and 80% sensitivity considering allocation in MI/HF+ and sham group, and 100% specificity and 58.8% sensitivity considering MI/HF+ and MI/HF- groups, taking into account pathological criteria of CHF diagnosis. Echocardiographic analysis can be used to accurately predict congestive heart failure in postinfarction rats.en
dc.description.affiliationUniv Estadual Paulista, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUniversidade Federal de Mato Grosso do Sul (UFMS), Sch Phys Therapy, Campo Grande, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu Biosci Inst, Dept Biostat, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Biosci Inst, Dept Biostat, Botucatu, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipIdCNPq: 304998/2009-5
dc.description.sponsorshipIdFAPESP: 07/59500-1
dc.description.sponsorshipIdFAPESP: 08/58655-4
dc.description.sponsorshipIdFUNDUNESP: 01197/08-DFP
dc.format.extent543-551
dc.identifierhttp://dx.doi.org/10.1152/japplphysiol.01154.2010
dc.identifier.citationJournal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 111, n. 2, p. 543-551, 2011.
dc.identifier.doi10.1152/japplphysiol.01154.2010
dc.identifier.issn8750-7587
dc.identifier.lattes9418970103564137
dc.identifier.lattes8727897080522289
dc.identifier.lattes4463138671998432
dc.identifier.lattes1590971576309420
dc.identifier.lattes5016839015394547
dc.identifier.urihttp://hdl.handle.net/11449/17119
dc.identifier.wosWOS:000293691900032
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofJournal of Applied Physiology
dc.relation.ispartofjcr3.256
dc.relation.ispartofsjr1,471
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectmyocardial infarctionen
dc.subjectechocardiographyen
dc.subjectcluster analysisen
dc.titleEchocardiographic detection of congestive heart failure in postinfarction ratsen
dc.typeArtigo
dcterms.licensehttp://www.the-aps.org/mm/Publications/Info-For-Authors/Copyright
dcterms.rightsHolderAmer Physiological Soc
unesp.author.lattes9418970103564137[12]
unesp.author.lattes8727897080522289[11]
unesp.author.lattes4463138671998432
unesp.author.lattes1590971576309420
unesp.author.lattes5016839015394547
unesp.author.orcid0000-0002-7719-9682[11]
unesp.author.orcid0000-0002-8895-9456[4]
unesp.author.orcid0000-0001-8980-8839[13]
unesp.author.orcid0000-0002-2579-5247[9]
unesp.author.orcid0000-0002-4402-6523[12]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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