Cholecalciferol in ethanol-preferring rats muscle fibers increases the number and area of type II fibers

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dc.contributor.authorGuidi Pinto, Carina [UNESP]
dc.contributor.authorColombo Marchi, Kátia
dc.contributor.authorAmarante Arizza, Ailton [UNESP]
dc.contributor.authorSilveira Leite, Ana Paula [UNESP]
dc.contributor.authorTirapelli, Carlos Renato
dc.contributor.authorMichelin Matheus, Selma Maria [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSchool of Medicine from Ribeirão Preto
dc.date.accessioned2018-12-11T16:55:22Z
dc.date.available2018-12-11T16:55:22Z
dc.date.issued2018-01-01
dc.description.abstractThe chronic use of ethanol causes neuropathy and atrophy of type II fibers and promotes vitamin D decrease. This study evaluated cholecalciferol effects on the deep fibular nerve and extensor digitorum longus (EDL) muscle using an UChB ethanol-preferring rats model. Blood analyses were carried out to measure levels of 25-hydroxycholecalciferol (25(OH)D), calcium (Ca2+), Phosphorus (P), and parathyroid hormone (PTH). It was used EDL muscle to evaluate oxidative stress. The deep fibular nerve and EDL muscle were used for morphologic and morphometric assessment. 25(OH)D plasma levels were higher in the supplemented group and no alterations were observed in other parameters including the oxidative stress evaluation. The G ratio remained constant which indicates nervous conduction normality. Cholecalciferol supplementation promoted an increase in the number and area of type II fibers and a decrease in the area of type I fibers. In the studied model, there was neither alcoholic myopathy nor neuropathy. The EDL muscle glycolytic patterns in the high-drinker UChB rats may be associated with the differential effects of cholecalciferol on metabolism and protein synthesis in skeletal muscle.en
dc.description.affiliationGeneral Bases of Surgery Medical School São Paulo State University (UNESP)
dc.description.affiliationDepartment of Pharmacology School of Medicine from Ribeirão Preto
dc.description.affiliationUndergraduate Student UNESP Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Anatomy Institute of Biosciences São Paulo State University
dc.description.affiliationUnespGeneral Bases of Surgery Medical School São Paulo State University (UNESP)
dc.description.affiliationUnespUndergraduate Student UNESP Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Anatomy Institute of Biosciences São Paulo State University
dc.identifierhttp://dx.doi.org/10.1016/j.acthis.2018.09.004
dc.identifier.citationActa Histochemica.
dc.identifier.doi10.1016/j.acthis.2018.09.004
dc.identifier.file2-s2.0-85053222682.pdf
dc.identifier.issn1618-0372
dc.identifier.issn0065-1281
dc.identifier.scopus2-s2.0-85053222682
dc.identifier.urihttp://hdl.handle.net/11449/171446
dc.language.isoeng
dc.relation.ispartofActa Histochemica
dc.relation.ispartofsjr0,661
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCholecalciferol
dc.subjectEthanol-preferring rats
dc.subjectI and II type muscle fibers
dc.subjectUChB rats
dc.titleCholecalciferol in ethanol-preferring rats muscle fibers increases the number and area of type II fibersen
dc.typeArtigo
unesp.author.orcid0000-0002-3079-4468[1]

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