Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep

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dc.contributor.authorJaramillo-Hernández, Dumar Alexander
dc.contributor.authorTamayo Rojas, Doris Juliette
dc.contributor.authorCifuentes Sánchez, Diana Consuelo [UNESP]
dc.contributor.authorVeloza Angulo, Luis Carlos
dc.contributor.authorMolina Diaz, Víctor Manuel
dc.contributor.authorPedraza Castillo, Luz Natalia
dc.contributor.authorRoque Rodriguez, Anita Isabel
dc.contributor.institutionUniversidad de los Llanos
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidad CES
dc.contributor.institutionTechnical Services
dc.date.accessioned2022-04-28T19:52:00Z
dc.date.available2022-04-28T19:52:00Z
dc.date.issued2021-01-01
dc.description.abstractThe aim of this study was to evaluate the potential for subchronic intoxication of Crotalaria pallida in sheep. Six rams were used, fed with hay and drinking water ad libitum, and 200 g/animal/day of commercial balanced ration. The sheep were distributed into a control group (G1) with two animals and an experimental group (G2) with four animals. In the G2 diet, 8 g of dry matter (DM) of C. pallida per kilogram of body weight were included for 28 days. All animals were clinically evaluated every 24 h. Animals were weighed and blood samples were taken for hemogram and liver and kidney profile on days 0, 14 and 28 post-exposure to C. pallida. All animals were slaughtered at the end of the study and samples were collected for histopathological analysis. No significant differences were found between groups with respect to clinical examination, hemogram data and blood chemistry; however, the histopathological study showed moderate thickening of the alveolar septa in the lung, severe vacuolar change in the liver, and moderate proteinuria in the kidney in the animals exposed to C. pallida.en
dc.description.affiliationEscuela de Ciencias Animales Facultad de Ciencias Agropecuarias y Recursos Naturales Universidad de los Llanos, Meta
dc.description.affiliationGrupo de Investigación en Farmacología Experimental y Medicina Interna Universidad de los Llanos, Meta
dc.description.affiliationClínica de las Intoxicaciones y Plantas Tóxicas Universidade Estadual Paulista Júlio de Mesquita filho
dc.description.affiliationFacultad de Medicina Veterinaria y Zootecnia Laboratorio de Patología Universidad CES
dc.description.affiliationBoehringer Ingelheim ROPU Surámerica Technical Services
dc.description.affiliationUnespClínica de las Intoxicaciones y Plantas Tóxicas Universidade Estadual Paulista Júlio de Mesquita filho
dc.identifierhttp://dx.doi.org/10.15381/RIVEP.V32I6.19923
dc.identifier.citationRevista de Investigaciones Veterinarias del Peru, v. 32, n. 6, 2021.
dc.identifier.doi10.15381/RIVEP.V32I6.19923
dc.identifier.issn1609-9117
dc.identifier.issn1682-3419
dc.identifier.scopus2-s2.0-85126482548
dc.identifier.urihttp://hdl.handle.net/11449/223663
dc.language.isospa
dc.relation.ispartofRevista de Investigaciones Veterinarias del Peru
dc.sourceScopus
dc.subjectMonocrotaline
dc.subjectPyrrolizidine alkaloids
dc.subjectToxic plants
dc.subjectToxicity
dc.titlePneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheepen
dc.titleNeumotoxicidad y hepatotoxicidad por Crotalaria pallida en el modelo de intoxicación subcrónica en ovinoses
dc.typeArtigo

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