Acute 2,4-dichlorophenoxyacetic acid intoxication in broiler chicks

Página do item simplificado
dc.contributor.authorMorgulis, M. S. F. A.
dc.contributor.authorOliveira, G. H. [UNESP]
dc.contributor.authorDagli, M. L. Z.
dc.contributor.authorPalermo-Neto, J.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:40Z
dc.date.available2014-05-20T13:24:40Z
dc.date.issued1998-04-01
dc.description.abstractThe acute toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D), a herbicide, was studied in chicks dosed with 100, 300, 500, or 600 mg 2,4-D/kg BW, by the oral route. Clinical, laboratory, and histopathological methods were used as indicators of toxicity. After acute exposure, the herbicide decreased motor activity and induced muscular weakness and motor incoordination; decreased weight gain; increased serum creatine kinase (CK) and alkaline phosphatase (AP) activities and serum uric acid (UA), creatinine (CR), and total proteins (TP) levels; and did not change serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) activities. These changes were time-and dose-dependent and reversible. The LD50 (lethal dose 50%) calculated for oral 2,4-D in chicks was 420 mg/kg BW (385 to 483). Chromatographic analysis of the serum of the intoxicated chicks showed the presence of the herbicide; the amount found was dose-and time-dependent, increasing from 2 to 8 h after exposure and decreasing afterwards. Histopathological post-mortem studies conducted on intoxicated chicks showed hepatic (vacuolar degeneration of the hepatocytes), renal (tubular nephrosis), and intestinal (hemorragic) lesions. Taken together, the observed alterations mainly reflected kidney and muscle tissue damage, although hepatic toxicity may also have occurred after acute 2,4-D intoxication.en
dc.description.affiliationUniv São Paulo, Sch Vet Med, Dept Pathol, Res Ctr Vet Toxicol,CEPTOX, BR-05508900 São Paulo, Brazil
dc.description.affiliationUNESP, Sch Pharmaceut Sci, Dept Nat Act Principles, Araraquara, SP, Brazil
dc.description.affiliationUnespDepartment of Natural Active Principles, School of Pharmaceutical Sciences UNESP, Araraquara, SP, Brazil
dc.format.extent509-515
dc.identifierhttp://dx.doi.org/10.1093/ps/77.4.509
dc.identifier.citationPoultry Science. Savoy: Poultry Science Associação Inc., v. 77, n. 4, p. 509-515, 1998.
dc.identifier.doi10.1093/ps/77.4.509
dc.identifier.issn0032-5791
dc.identifier.scopus2-s2.0-0032042015
dc.identifier.urihttp://hdl.handle.net/11449/7727
dc.identifier.wosWOS:000072940700003
dc.language.isoeng
dc.publisherPoultry Science Assoc Inc
dc.relation.ispartofPoultry Science
dc.relation.ispartofjcr2.216
dc.relation.ispartofsjr1,112
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subject2,4-dichlorophenoxyacetic acidpt
dc.subjectherbicidept
dc.subjectintoxicationpt
dc.subjectbroilerpt
dc.subjectpesticidept
dc.titleAcute 2,4-dichlorophenoxyacetic acid intoxication in broiler chicksen
dc.typeArtigo
dcterms.licensehttp://japr.fass.org/site/misc/Rights_Permissions.xhtml
dcterms.rightsHolderPoultry Science Associação Inc
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR