Aging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluations

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dc.contributor.authorCustodio, Ana Maria G.
dc.contributor.authorSantos, Fernanda C. A. [UNESP]
dc.contributor.authorCampos, Silvana G. P. [UNESP]
dc.contributor.authorVilamaior, Patricia S. L. [UNESP]
dc.contributor.authorGoes, Rejane M. [UNESP]
dc.contributor.authorTaboga, Sebastiao R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUNIRP
dc.date.accessioned2014-05-20T14:00:57Z
dc.date.available2014-05-20T14:00:57Z
dc.date.issued2008-04-01
dc.description.abstractDifferent from the classic view, the prostate is not a gland exclusive to the male, also being an organ of the female genital system presenting morphofunctional similarity between human and rodent. Thus structural, ultrastructural, morphometric-stereological features of the female prostate (Skene's paraurethral gland) and steroid serological levels were evaluated during young, adult, and senile ages in the Mongolian gerbil. The morphofunctional precocity of the female gland in comparison with the male gland occurring in young gland is probably associated with the female circulating steroid levels. The hormonal imbalance in senesce coincides with its susceptibility to histopathological lesions, such as epithelial hypertrophy, metaplasia, and intraepithelial neoplasia. Differently than that of males, the aging degeneration of the female gland involves the accumulation of lipofuscin granules. However, the alterations in senile prostate did not damage its functionality. These analyses reinforce the use of this experimental model for the comprehension of glandular morphofunctional aspects with special attention to senescence. Thus, the appreciation of this organ becomes relevant to avoid future discomfort to women's health.en
dc.description.affiliationUNESP, IBILCE, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Cell Biol, Campinas, SP, Brazil
dc.description.affiliationUNIRP, Biol Sci & Vet Med Sch, Rio Preto Univ Ctr, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, IBILCE, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.format.extent463-474
dc.identifierhttp://dx.doi.org/10.1002/ar.20637
dc.identifier.citationAnatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Hoboken: Wiley-liss, v. 291, n. 4, p. 463-474, 2008.
dc.identifier.doi10.1002/ar.20637
dc.identifier.issn1932-8486
dc.identifier.lattes7066358123790434
dc.identifier.lattes0947193347312157
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0001-9559-5497
dc.identifier.orcid0000-0002-3622-460X
dc.identifier.urihttp://hdl.handle.net/11449/21535
dc.identifier.wosWOS:000254127400010
dc.language.isoeng
dc.publisherWiley-liss
dc.relation.ispartofAnatomical Record-advances In Integrative Anatomy and Evolutionary Biology
dc.relation.ispartofjcr1.373
dc.relation.ispartofsjr0,766
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectfemale prostateen
dc.subjectMongolian gerbilen
dc.subjectagingen
dc.subjectsteroids hormonesen
dc.subjecthistopathologyen
dc.subjectultrastructureen
dc.titleAging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluationsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-liss
unesp.author.lattes7066358123790434[4]
unesp.author.lattes0947193347312157[5]
unesp.author.orcid0000-0001-9559-5497[4]
unesp.author.orcid0000-0002-0970-4288[6]
unesp.author.orcid0000-0002-3622-460X[5]

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Botucatu - CME - Centro de Microscopia Eletrônica