Homogenous amniotic membrane as a biological dressing for oral mucositis in rats: Histomorphometric analysis

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dc.contributor.authorVilela-Goulart, Maria das Gracas
dc.contributor.authorSantos Teixeira, Raquel Teodoro
dc.contributor.authorRanyel, Daniela Coelho [UNESP]
dc.contributor.authorNiccoli-Filho, Walter
dc.contributor.authorGomes, Monica Fernandes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAssoc ProSaúde Pacientes Necessidades Especiais A
dc.date.accessioned2014-05-20T14:04:26Z
dc.date.available2014-05-20T14:04:26Z
dc.date.issued2008-12-01
dc.description.abstractObjective: oral mucositis is a frequent and significant side effect of chemotherapy and/or radiation therapy. The purpose of this study was to evaluate the effects of the homogenous amniotic membrane (HAM) as a biological dressing for oral mucositis induced by 5-fluorouracil (5-FU) in the labial fornix region of inferior incisors in rats.Methods: Sixty rats were divided into three groups: control (50% acetic acid), 5-FU (50% acetic acid and 5-fluorouracil-induced oral mucositis) and 5-FU + HAM (50% acetic acid and 5fluorouracil-induced oral mucositis, and treated with HAM). Histological analyses were done 3, 7, 14 and 21 days after applying the acetic acid.Results: HAM showed not only no signs of rejection as well as an excellent tissue adherence to the ulcerated surface. Histomorphometric analysis indicated a lower quantity of inflammatory cells in the 5-FU + HAM group in all periods when compared to the other groups and there was a statistically significant difference in the 3- and 7-day periods (P < 0.001).Conclusions: The results of this study suggest that HAM was biocompatible with great adhesive power to the ulcerated surface, accelerated the healing process and exhibited anti-inflammatory activity. Further studies should be done to investigate the potential benefits of this material in clinical trials. HAM could lead to improved results as a biological dressing in treatment and management of oral mucositis in patients submitted to chemotherapy and/or radiation therapy. (C) 2008 Elsevier Ltd. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP,Ctr Biociencias Aplicado Pacientes Necessid, Sao Jose Campos Dent Sch,CEBAPE, Dept Biosci & Oral Diag,Biosci Ctr Special Hlth C, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationAssoc ProSaúde Pacientes Necessidades Especiais A, Special Hlth Care Needs Assoc, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Sao Jose Campos Dent Sch, Dept Diag & Surg, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP,Ctr Biociencias Aplicado Pacientes Necessid, Sao Jose Campos Dent Sch,CEBAPE, Dept Biosci & Oral Diag,Biosci Ctr Special Hlth C, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sao Jose Campos Dent Sch, Dept Diag & Surg, Sao Jose Dos Campos, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 04/04447-0
dc.format.extent1163-1171
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2008.07.003
dc.identifier.citationArchives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 53, n. 12, p. 1163-1171, 2008.
dc.identifier.doi10.1016/j.archoralbio.2008.07.003
dc.identifier.issn0003-9969
dc.identifier.lattes1274225455678400
dc.identifier.urihttp://hdl.handle.net/11449/22607
dc.identifier.wosWOS:000260941200009
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofArchives of Oral Biology
dc.relation.ispartofjcr2.050
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHomogenous amniotic membraneen
dc.subjectBiological dressingen
dc.subjectOral mucositisen
dc.subjectHealing processen
dc.subject5-Fluorouracilen
dc.titleHomogenous amniotic membrane as a biological dressing for oral mucositis in rats: Histomorphometric analysisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes1274225455678400
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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