Levels of MMP-9 in patients with intracranial aneurysm: Relation with risk factors, size and clinical presentation

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dc.contributor.authorRojas, Hugo Alberto
dc.contributor.authorFernandes, Karla Simone da Silva
dc.contributor.authorOttone, Mariana Rodrigues
dc.contributor.authorMagalhães, Kênia Cristina S. Fonseca de
dc.contributor.authorAlbuquerque, Lucas Alverne Freitas de
dc.contributor.authorPereira, Julio Leonardo Barbosa
dc.contributor.authorVieira-Júnior, Gerival
dc.contributor.authorSousa-Filho, José Lopes
dc.contributor.authorCosta, Bruno Silva
dc.contributor.authorSandrim, Valéria Cristina [UNESP]
dc.contributor.authorDellaretti, Marcos
dc.contributor.authorSimões, Renata Toscano
dc.contributor.institutionInstitute of Education and Research of Santa Casa de Belo Horizonte Hospital - IEP/SCBH
dc.contributor.institutionNeurosurgery Service - Santa Casa de Belo Horizonte Hospital
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:18:43Z
dc.date.available2018-12-11T17:18:43Z
dc.date.issued2018-05-01
dc.description.abstractBackground: Intracranial aneurysms are arterial anomalies affecting 2% to 3% of the general population in the world and these ruptures are associated with a high mortality. Some risk factors, such as age, gender, smoking, alcohol, hypertension and familial history are associated with the number of aneurysms and their size. In addition, inflammatory processes within the blood vessels of the brain can activate matrix metalloproteinase-9 (MMP-9), which degrades various components of the extracellular matrix, such as elastin. Thereby, this work has aimed at evaluating the relationship between plasma MMP-9 levels and the risk factors that are associated with intracranial aneurysm, as well as investigating the aneurysm statuses (ruptured and unruptured) and comparing them with the control volunteers. Methods: Between August 2014 to June 2016, blood samples were collected from 282 patients (204 ruptured and 78 unruptured saccular intracranial aneurysms) and 286 control volunteers. The MMP-9 plasma levels were measured by ELISA. Statistical analyzes were performed with SPSS software when using parametric or nonparametric tests, after the normality tests. Results: Higher levels of MMP-9 were found in the aneurysm groups as a whole and when they were stratified by rupture status, then compared with the control group (p < 0.0001). When stratifying them by diameter, those smaller than 7 mm presented high levels of MMP-9 (p < 0.0001), especially in the ruptured ones. As for risk factors, hypertension and smoking were the most important. However, hypertension was mostly associated with the ruptured aneurysms (p < 0.0001). Conclusions: High levels of MMP-9 were found in smaller ruptured and unruptured intracranial aneurysms (<7 mm) with strongest statistical associations than other sizes, especially when associated with smoking and hypertension.en
dc.description.affiliationInstitute of Education and Research of Santa Casa de Belo Horizonte Hospital - IEP/SCBH
dc.description.affiliationNeurosurgery Service - Santa Casa de Belo Horizonte Hospital
dc.description.affiliationDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)
dc.description.affiliationUnespDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPEMIG: APQ-02010-14
dc.description.sponsorshipIdCAPES: PEC-PG n°15138127
dc.format.extent63-68
dc.identifierhttp://dx.doi.org/10.1016/j.clinbiochem.2018.03.005
dc.identifier.citationClinical Biochemistry, v. 55, p. 63-68.
dc.identifier.doi10.1016/j.clinbiochem.2018.03.005
dc.identifier.file2-s2.0-85044281335.pdf
dc.identifier.issn1873-2933
dc.identifier.issn0009-9120
dc.identifier.scopus2-s2.0-85044281335
dc.identifier.urihttp://hdl.handle.net/11449/176052
dc.language.isoeng
dc.relation.ispartofClinical Biochemistry
dc.relation.ispartofsjr0,984
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectGelatinase-B
dc.subjectIntracranial aneurysm
dc.subjectMetalloproteinase-9
dc.subjectSubarachnoid hemorrhage
dc.titleLevels of MMP-9 in patients with intracranial aneurysm: Relation with risk factors, size and clinical presentationen
dc.typeArtigo

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