Physicochemical properties and effect of bioceramic root canal filling for primary teeth on osteoblast biology

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dc.contributor.authorOchoa Rodríguez, Victor Manuel [UNESP]
dc.contributor.authorTanomaru-Filho, Mario [UNESP]
dc.contributor.authorRodrigues, Elisandra Márcia [UNESP]
dc.contributor.authorBugança, Eduarda de Oliveira [UNESP]
dc.contributor.authorGuerreiro-Tanomaru, Juliane Maria [UNESP]
dc.contributor.authorFaria, Gisele [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T10:59:39Z
dc.date.available2021-06-25T10:59:39Z
dc.date.issued2021-01-01
dc.description.abstractOBJECTIVE: Bio-C Pulpecto (Bio-CP) was recently developed as the first bioceramic root filling material for primary teeth. To evaluate the physicochemical properties of radiopacity, setting time, pH, cytocompatibility and potential of Bio-CP to induce mineralisation, compared with (1) Calen thickened with zinc oxide (Calen-ZO), and (2) zinc oxide and eugenol (ZOE). METHODOLOGY: Physicochemical properties were evaluated according to ISO 6876. Saos-2 (human osteoblast-like cell line) exposed to extracts of the materials were subjected to assays of methyl thiazolyl tetrazolium, neutral red, alkaline phosphatase (ALP) activity and mineralised nodule production. The results were analysed using one-way or two-way ANOVA and Tukey's or Bonferroni's post-tests (α=0.05). RESULTS: All the materials showed radiopacity higher than 3 mm Al. Bio-CP had lower pH than Calen-ZO, but higher pH than ZOE. Calen-ZO and Bio-CP did not set. The setting time for ZOE was 110 min. The cytocompatibility order was Calen-ZO > Bio-CP > ZOE (1:2, 1:4 dilutions) and Calen-ZO > Bio-CP = ZOE (1:12, 1:24 dilutions) and Calen-ZO = Bio-CP > ZOE (1:32 dilution). Bio-CP induced greater ALP activity at 7 days, and greater mineralised nodule production, compared to Calen-ZO (p<0.05). Conclusions Bio-CP showed adequate physicochemical properties, cytocompatibility and potential to induce mineralisation.en
dc.description.affiliationUniversidade Estadual Paulista Julio de Mesquita Fillho (UNESP) - Faculdade de Odontologia de Araraquara - Departamento de Odontologia Restauradora - Araraquara - SP - Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Julio de Mesquita Fillho (UNESP) - Faculdade de Odontologia de Araraquara - Departamento de Odontologia Restauradora - Araraquara - SP - Brasil
dc.format.extente20200870
dc.identifierhttp://dx.doi.org/10.1590/1678-7757-2020-0870
dc.identifier.citationJournal of applied oral science : revista FOB, v. 29, p. e20200870-.
dc.identifier.doi10.1590/1678-7757-2020-0870
dc.identifier.fileS1678-77572021000100422.pdf
dc.identifier.issn1678-7765
dc.identifier.scieloS1678-77572021000100422
dc.identifier.scopus2-s2.0-85105470997
dc.identifier.urihttp://hdl.handle.net/11449/207708
dc.language.isoeng
dc.relation.ispartofJournal of applied oral science : revista FOB
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titlePhysicochemical properties and effect of bioceramic root canal filling for primary teeth on osteoblast biologyen
dc.typeArtigo
unesp.author.orcid0000-0003-0596-6683[1]
unesp.author.orcid0000-0002-2574-4706[2]
unesp.author.orcid0000-0002-1609-2507[3]
unesp.author.orcid0000-0002-9489-7319[4]
unesp.author.orcid0000-0003-0446-2037[5]
unesp.author.orcid0000-0001-7030-3718[6]

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