Commissural nucleus of the solitary tract is important for cardiovascular responses to caudal pressor area activation

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dc.contributor.authorTakakura, Ana Carolina
dc.contributor.authorMoreira, Thiago Santos
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorCampos, Ruy Ribeiro
dc.contributor.authorColombaria, Eduardo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:45:38Z
dc.date.available2014-05-20T13:45:38Z
dc.date.issued2007-08-03
dc.description.abstractThe nucleus of the solitary tract (NTS) is the site of the first synapse of cardiovascular afferent fibers in the central nervous system. Important mechanisms for cardiovascular regulation are also present in the caudal pressor area (CPA) localized at the caudal end of the ventrolateral medulla. In the present study we sought to investigate the role of the commissural subnucleus of the NTS (commNTS) on pressor and tachycardic responses induced by L-glutamate injected into the CPA. Male Holtzman rats (n=8 rats/group) anesthetized with urethane (1.2 g/kg of body weight, iv) received injections of the GABAA receptor agonist muscimol into the commNTS. Unilateral injection of L-glutamate (10 nmol/ 100 nL) into the CPA increased mean arterial pressure (MAP, 31 4 mm Hg, vs. saline: 3 +/- 2 mm Hg) and heart rate (HR, 44 8 bpm, vs. saline: 10 7 bpm). inhibition of commNTS neurons with muscimol (120 pmol/60 nL) abolished the increase in MAP (9 4 mm Hg) and HR (17 7 bpm) produced by L-glutamate into the CPA. The present results suggest that the pressor and tachycardic responses to CPA activation are dependent on commNTS mechanisms.en
dc.description.affiliationUniv Fed São Paulo EPM, Dept Phys, BR-04023060 São Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Fac Odontol, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Fac Odontol, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.format.extent32-37
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2007.05.059
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1161, p. 32-37, 2007.
dc.identifier.doi10.1016/j.brainres.2007.05.059
dc.identifier.issn0006-8993
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16055
dc.identifier.wosWOS:000248891300004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectventrolateral medullapt
dc.subjectsympatheticpt
dc.subjecthypertensionpt
dc.subjectexcitatory amino acidpt
dc.subjectMuscimolpt
dc.subjectNTSpt
dc.subjectCPApt
dc.titleCommissural nucleus of the solitary tract is important for cardiovascular responses to caudal pressor area activationen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0002-1395-4036[5]
unesp.author.orcid0000-0003-1167-4441[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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