Cytomorphologic Evidenceof Human Papillomavirus Infection in Smears from the IrradiatedUterine Cervix

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dc.contributor.authorLongatto Filho, Adhemar [UNESP]
dc.contributor.authorSakamoto Maeda, Marina Yoshie [UNESP]
dc.contributor.authorOyafuso, Marina Suheko [UNESP]
dc.contributor.authorAlves, Venancio Avancini Ferreira [UNESP]
dc.contributor.authorKanamura, Cristina Takami [UNESP]
dc.contributor.authorBortolan, Jeni [UNESP]
dc.contributor.institutionAdolfo Lutz Institute
dc.contributor.institutionA. C. Camargo Hospital
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:59:54Z
dc.date.available2022-04-28T19:59:54Z
dc.date.issued1997-01-01
dc.description.abstractOBJECTIVE: To report the cytomorphologic evidence of human papillomavirus (HPV) infection in cervical smears from women treated with radiotherapy for carcinoma of the uterine cervix. STUDY DESIGN: From January 1986 to December 1993, 32 cervical cytologic smears (CCSs) from women who had received radiotherapy (Rtx) for squamous cell cervical carcinoma at A. C. CamargoCancer Hospital were selected for study due to the presence of signs of HPV infection. Review of the files of these patients showed 22 additional samples, which we included in this study. The avidinbiotin- immunoperoxidase technique was performed on previously stained slides using polyclonal rabbit antibovine papillomavirus type 1 to confirm the HPV infection. RESULTS: Positive reactions were found in 18 cases (27 samples), mainly in cells with classic koilocytotic features, but also in epithelial cells that lacked cytopathic effects. Only one case, a biopsy from a verrucous lesion observed after Rtx, was found to be positive for HPV 6/11 DNA by in situ hybridization. CONCLUSION: Cytologic and immunohistochemical positivity for HPV, as well as the reaction with a HPV 6/11 DNA probe, strongly suggested that HPV infection was acquired or expressed after radiotherapy. Further studies are needed to assess the mechanisms responsible forsuch an association. © 1997 The International Academy of Cytology Acta Cytologica.en
dc.description.affiliationPathology Division Adolfo Lutz Institute
dc.description.affiliationPathology Department A. C. Camargo Hospital
dc.description.affiliationDepartment of Pathology São Paulo State University Medical School, São Paulo
dc.description.affiliationA. C. Camargo Hospital Adolfo Lutz Institute
dc.description.affiliationAdolfo Lutz Institute São Paulo State University Medical School
dc.description.affiliationA. C. Camargo Hospital
dc.description.affiliationUnespDepartment of Pathology São Paulo State University Medical School, São Paulo
dc.description.affiliationUnespAdolfo Lutz Institute São Paulo State University Medical School
dc.format.extent1079-1084
dc.identifierhttp://dx.doi.org/10.1159/000332791
dc.identifier.citationActa Cytologica, v. 41, n. 4, p. 1079-1084, 1997.
dc.identifier.doi10.1159/000332791
dc.identifier.issn1938-2650
dc.identifier.issn0001-5547
dc.identifier.scopus2-s2.0-1842332075
dc.identifier.urihttp://hdl.handle.net/11449/224532
dc.language.isoeng
dc.relation.ispartofActa Cytologica
dc.sourceScopus
dc.subjectCervix neoplasms
dc.subjectHuman
dc.subjectPapillomavirus
dc.subjectRadiotherapy
dc.titleCytomorphologic Evidenceof Human Papillomavirus Infection in Smears from the IrradiatedUterine Cervixen
dc.typeArtigo

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