Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

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dc.contributor.authorCalistro Neto, José Pedro [UNESP]
dc.contributor.authorTorres, Rômulo da Costa [UNESP]
dc.contributor.authorGonçalves, Giovanna Maria [UNESP]
dc.contributor.authorSilva, Leopoldo Muniz da [UNESP]
dc.contributor.authorDomingues, Maria Aparecida Custódio [UNESP]
dc.contributor.authorMódolo, Norma Sueli Pinheiro [UNESP]
dc.contributor.authorBarros, Guilherme Antonio Moreira de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-08-26T19:22:37Z
dc.date.available2015-08-26T19:22:37Z
dc.date.issued2015-04-01
dc.description.abstractTo evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model.en
dc.description.affiliationUNESP
dc.description.affiliationUnespPostgraduate Program in Anesthesiology, Botucatu Medical School, Sao Paulo State University (UNESP), Brazil. Conception, design, intellectual and scientific content of the study
dc.description.affiliationUnespDepartment of Pathology, Botucatu Medical School, UNESP, Botucatu-SP, Brazil. Acquisition and interpretation of data, histological examinations
dc.format.extent270-276
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270&lng=en&nrm=iso&tlng=en
dc.identifier.citationActa Cirurgica Brasileira, v. 30, n. 4, p. 270-276, 2015.
dc.identifier.doi10.1590/S0102-865020150040000006
dc.identifier.fileS0102-86502015000400270.pdf
dc.identifier.issn0102-8650
dc.identifier.lattes8223546475724058
dc.identifier.lattes0585723113037140
dc.identifier.scieloS0102-86502015000400270
dc.identifier.urihttp://hdl.handle.net/11449/127513
dc.language.isoeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.ispartofjcr0.933
dc.relation.ispartofsjr0,395
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectParecoxiben
dc.subjectIschemiaen
dc.subjectReperfusionen
dc.subjectKidneyen
dc.subjectRatsen
dc.titleParecoxib reduces renal injury in an ischemia/reperfusion model in ratsen
dc.typeArtigo
unesp.author.lattes8223546475724058
unesp.author.lattes0585723113037140
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Arquitetura, Artes, Comunicação e Design, Baurupt
unesp.departmentDesign - FAACpt

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