Paraventricular nucleus of the hypothalamus glutamate neurotransmission modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats

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dc.contributor.authorBusnardo, Cristiane
dc.contributor.authorAlves, Fernando H.F.
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.authorScopinho, América A.
dc.contributor.authorResstel, Leonardo B.M.
dc.contributor.authorCorrea, Fernando M.A.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:27:10Z
dc.date.available2014-05-27T11:27:10Z
dc.date.issued2012-11-30
dc.description.abstractIn the present study, the involvement of paraventricular nucleus of the hypothalamus (PVN) glutamate receptors in the modulation of autonomic (arterial blood pressure, heart rate and tail skin temperature) and neuroendocrine (plasma corticosterone) responses and behavioral consequences evoked by the acute restraint stress in rats was investigated. The bilateral microinjection of the selective non-NMDA glutamate receptor antagonist NBQX (2 nmol/ 100 nL) into the PVN reduced the arterial pressure increase as well as the fall in the tail cutaneous temperature induced by the restraint stress, without affecting the stress-induced tachycardiac response. On the other hand, the pretreatment of the PVN with the selective NMDA glutamate receptor antagonist LY235959 (2 nmol/100 nL) was able to increase the stress-evoked pressor and tachycardiac response, without affecting the fall in the cutaneous tail temperature. The treatment of the PVN with LY235959 also reduced the increase in plasma corticosterone levels during stress and inhibited the anxiogenic-like effect observed in the elevated plus-maze 24 h after the restraint session. The present results show that NMDA and non-NMDA receptors in the PVN differently modulate responses associated to stress. The PVN glutamate neurotransmission, via non-NMDA receptors, has a facilitatory influence on stress-evoked autonomic responses. On the other hand, the present data point to an inhibitory role of PVN NMDA receptors on the cardiovascular responses to stress. Moreover, our findings also indicate an involvement of PVN NMDA glutamate receptors in the mediation of the plasma corticosterone response as well as in the delayed emotional consequences induced by the restraint stress. © 2012 Elsevier B.V. and ECNP.en
dc.identifierhttp://dx.doi.org/10.1016/j.euroneuro.2012.11.002
dc.identifier.citationEuropean Neuropsychopharmacology.
dc.identifier.doi10.1016/j.euroneuro.2012.11.002
dc.identifier.issn0924-977X
dc.identifier.issn1873-7862
dc.identifier.lattes1117432571971568
dc.identifier.scopus2-s2.0-84870057479
dc.identifier.urihttp://hdl.handle.net/11449/73767
dc.identifier.wosWOS:000328014700031
dc.language.isoeng
dc.relation.ispartofEuropean Neuropsychopharmacology
dc.relation.ispartofjcr4.129
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAnxiety
dc.subjectCardiovascular
dc.subjectElevated plus maze test
dc.subjectHPA axis
dc.subjectNMDA glutamate receptors
dc.subjectNon-NMDA glutamate receptors
dc.subjectPVN
dc.subjectStress
dc.titleParaventricular nucleus of the hypothalamus glutamate neurotransmission modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes1117432571971568[3]
unesp.author.orcid0000-0002-1942-858X[3]
unesp.author.orcid0000-0003-4067-9524[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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