Exposure to ethinylestradiol during prenatal development and postnatal supplementation with testosterone causes morphophysiological alterations in the prostate of male and female adult gerbils

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dc.contributor.authorSilva Perez, Ana Paula
dc.contributor.authorBiancardi, Manoel Francisco
dc.contributor.authorGoes, Rejane Maira
dc.contributor.authordos Santos, Fernanda Alcantara
dc.contributor.authorTaboga, Sebastiao Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2014-05-20T14:00:51Z
dc.date.available2014-05-20T14:00:51Z
dc.date.issued2011-04-01
dc.description.abstractP>Steroids perform significant functions in prostatic development and growth, so that interferences of this equilibrium may predispose the gland to the development of diseases during the life. Embryonic and neonatal exposure to xenoestrogens, many of them with endocrine-disrupting potential, has been related to the induction of disturbances in reproductive system organs. Thus, this study aimed to analyse morphological and immunocytochemical aspects of prostate in both male and female adult gerbils either exposed to ethinylestradiol during the prenatal phase (pregnant females received 10 mu g/kg, by gavage) (EE group) or exposed to testosterone (1 mg/kg) during the postnatal period (EE/T group). Serological analysis revealed a rise in estradiol levels in adult males and females of the EE group. A higher incidence of prostatic intraepithelial neoplasia (PIN) was observed in the male and female prostate of the treated groups, besides an increase in collagen and reticular fibres. Immunocytochemistry showed an increase in prostatic epithelial cells immunoreactive to AR and a presence of a smooth muscle layer, evidenced by alpha actin, in injured regions this way absent in prostatic epithelial buds. These pieces of evidence suggest that the alterations verified in the prostate in adulthood of both sexes may be due to the high oestrogen levels. Either males or females of the EE/T group showed normalized estradiol levels, although prostatic lesions could be observed. While the prostatic gland of male gerbils was more affected than the female prostate, this study showed that the exposure to EE during this critical period of development disrupts the prostate of both sexes in terms of prostatic lesions.en
dc.description.affiliationSão Paulo State Univ, IBILCE UNESP, Dept Biol,Lab Microscopy & Microanal, Inst Biosci Humanities & Exact Sci, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Grad Program Cell & Struct Biol, Inst Biol, Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de Goiás (UFG), Dept Morphol, Goiania, Go, Brazil
dc.description.affiliationUnespSão Paulo State Univ, IBILCE UNESP, Dept Biol,Lab Microscopy & Microanal, Inst Biosci Humanities & Exact Sci, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 07/06234-2
dc.description.sponsorshipIdCNPq: 300163/08-8
dc.format.extent121-130
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2613.2010.00756.x
dc.identifier.citationInternational Journal of Experimental Pathology. Malden: Wiley-blackwell, v. 92, n. 2, p. 121-130, 2011.
dc.identifier.doi10.1111/j.1365-2613.2010.00756.x
dc.identifier.issn0959-9673
dc.identifier.lattes0947193347312157
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0002-3622-460X
dc.identifier.urihttp://hdl.handle.net/11449/21496
dc.identifier.wosWOS:000288679500007
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofInternational Journal of Experimental Pathology
dc.relation.ispartofjcr1.938
dc.relation.ispartofsjr0,712
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectethinylestradiolen
dc.subjectfemale prostateen
dc.subjectgerbilen
dc.subjectmale prostateen
dc.subjectprenatal developmenten
dc.titleExposure to ethinylestradiol during prenatal development and postnatal supplementation with testosterone causes morphophysiological alterations in the prostate of male and female adult gerbilsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes0947193347312157[3]
unesp.author.orcid0000-0002-3622-460X[3]
unesp.author.orcid0000-0002-0970-4288[5]
unesp.author.orcid0000-0001-9995-3546[2]
unesp.author.orcid0000-0002-3622-460X[3]

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Botucatu - CME - Centro de Microscopia Eletrônica