Impact of Glucose Exposure on Outcomes of a Nation-Wide Peritoneal Dialysis Cohort-Results of the BRAZPD II Cohort

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dc.contributor.authorRadunz, Vitor
dc.contributor.authorPecoits-Filho, Roberto
dc.contributor.authorFigueiredo, Ana Elizabeth
dc.contributor.authorBarretti, Pasqual [UNESP]
dc.contributor.authorMoraes, Thyago Proenca de
dc.contributor.institutionEscola Med
dc.contributor.institutionPontificia Univ Catolica Rio Grande do Sul
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-05T15:49:06Z
dc.date.available2019-10-05T15:49:06Z
dc.date.issued2019-03-05
dc.description.abstractBackground: Data investigating the association of glucose exposure with technique failure and patient survival are limited to retrospective cohorts and was never tested outside Asia and considering the presence of competing risks. Methods: Prospective multicenter cohort study of incident peritoneal dialysis patients where the association of cumulative glucose exposure in 6, 12, and 24 months with patient survival and technique failure was tested using Cox regression analysis and competing risk analysis. Results: We analyzed 4367 incident peritoneal dialysis patients with mean age 59.0 +/- 15.8 years, 43.9% were diabetics, 46.7% males and 64.4% Caucasians. Glucose exposure was not associated with patient survival independent of the time of exposure and even after adjustments for confounders. In contrast, higher glucose exposure was associated with more technique failure in the Cox and competing risk models. The higher risk for technique failure was found in the subgroup exposed to the higher amount of glucose to a maximum of 86% in the model analyzing cumulative glucose exposure for 1 year. Conclusion: Glucose exposure was associated with technique failure but not with patient survival.en
dc.description.affiliationEscola Med, Programa Posgrad Ciencias Saude, Curitiba, Parana, Brazil
dc.description.affiliationPontificia Univ Catolica Rio Grande do Sul, Programa Posgrad Med & Ciencies Saude Nefrol, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Botucatu, Botucatu, SP, Brazil
dc.format.extent8
dc.identifierhttp://dx.doi.org/10.3389/fphys.2019.00150
dc.identifier.citationFrontiers In Physiology. Lausanne: Frontiers Media Sa, v. 10, 8 p., 2019.
dc.identifier.doi10.3389/fphys.2019.00150
dc.identifier.issn1664-042X
dc.identifier.lattes5496411983893479
dc.identifier.orcid0000-0003-4979-4836
dc.identifier.urihttp://hdl.handle.net/11449/186664
dc.identifier.wosWOS:000460360200002
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Physiology
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectperitoneal dialysis
dc.subjectcohort
dc.subjectglucose
dc.subjectmembrane
dc.subjectdeath
dc.subjectultrafiltration failure
dc.titleImpact of Glucose Exposure on Outcomes of a Nation-Wide Peritoneal Dialysis Cohort-Results of the BRAZPD II Cohorten
dc.typeArtigo
dcterms.rightsHolderFrontiers Media Sa
unesp.author.lattes5496411983893479[4]
unesp.author.orcid0000-0002-8555-8649[3]
unesp.author.orcid0000-0003-4979-4836[4]

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