Chaotic and stochastic dynamics of epileptiform-like activities in sclerotic hippocampus resected from patients with pharmacoresistant epilepsy

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dc.contributor.authorAraújo, Noemi S.
dc.contributor.authorReyes-Garcia, Selvin Z.
dc.contributor.authorBrogin, João A.F. [UNESP]
dc.contributor.authorBueno, Douglas D. [UNESP]
dc.contributor.authorCavalheiro, Esper A.
dc.contributor.authorScorza, Carla A.
dc.contributor.authorFaber, Jean
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidad Nacional Autónoma de Honduras
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-03-01T20:39:39Z
dc.date.available2023-03-01T20:39:39Z
dc.date.issued2022-04-01
dc.description.abstractThe types of epileptiform activity occurring in the sclerotic hippocampus with highest incidence are interictal-like events (II) and periodic ictal spiking (PIS). These activities are classified according to their event rates, but it is still unclear if these rate differences are consequences of underlying physiological mechanisms. Identifying new and more specific information related to these two activities may bring insights to a better understanding about the epileptogenic process and new diagnosis. We applied Poincaré map analysis and Recurrence Quantification Analysis (RQA) onto 35 in vitro electrophysiological signals recorded from slices of 12 hippocampal tissues surgically resected from patients with pharmacoresistant temporal lobe epilepsy. These analyzes showed that the II activity is related to chaotic dynamics, whereas the PIS activity is related to deterministic periodic dynamics. Additionally, it indicates that their different rates are consequence of different endogenous dynamics. Finally, by using two computational models we were able to simulate the transition between II and PIS activities. The RQA was applied to different periods of these simulations to compare the recurrences between artificial and real signals, showing that different ranges of regularity-chaoticity can be directly associated with the generation of PIS and II activities.en
dc.description.affiliationDepartment of Neurology and Neurosurgery Federal University of São Paulo (UNIFESP)
dc.description.affiliationDepartamento de Ciencias Morfológicas Facultad de Ciencias Médicas Universidad Nacional Autónoma de Honduras
dc.description.affiliationDepartment of Mechanical Engineering São Paulo State University (UNESP) School of Engineering of Ilha Solteira, Ilha Solteira
dc.description.affiliationDepartment of Mathematics São Paulo State University (UNESP) School of Engineering of Ilha Solteira, Ilha Solteira
dc.description.affiliationUnespDepartment of Mechanical Engineering São Paulo State University (UNESP) School of Engineering of Ilha Solteira, Ilha Solteira
dc.description.affiliationUnespDepartment of Mathematics São Paulo State University (UNESP) School of Engineering of Ilha Solteira, Ilha Solteira
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipInstituto Nacional de Ciência e Tecnologia de Neurociência Translacional
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 15/24691-8
dc.description.sponsorshipIdCNPq: 442563-2016/7
dc.description.sponsorshipIdInstituto Nacional de Ciência e Tecnologia de Neurociência Translacional: 573604/2008-8
dc.identifierhttp://dx.doi.org/10.1371/journal.pcbi.1010027
dc.identifier.citationPLoS Computational Biology, v. 18, n. 4, 2022.
dc.identifier.doi10.1371/journal.pcbi.1010027
dc.identifier.issn1553-7358
dc.identifier.issn1553-734X
dc.identifier.scopus2-s2.0-85129475434
dc.identifier.urihttp://hdl.handle.net/11449/240942
dc.language.isoeng
dc.relation.ispartofPLoS Computational Biology
dc.sourceScopus
dc.titleChaotic and stochastic dynamics of epileptiform-like activities in sclerotic hippocampus resected from patients with pharmacoresistant epilepsyen
dc.typeArtigo

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Artigos - Matemática - FEIS