Experimental maxillary sinus augmentation using a highly bioactive glass ceramic

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dc.contributor.authorVivan, Rodrigo Ricci
dc.contributor.authorMecca, Carlos Eduardo
dc.contributor.authorBiguetti, Claudia Cristina
dc.contributor.authorRennó, Ana Claudia Muniz
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.authorCavenago, Bruno Cavalini
dc.contributor.authorDuarte, Marco Húngaro
dc.contributor.authorMatsumoto, Mariza Akemi [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSagrado Coração University – USC
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUSC
dc.contributor.institutionCNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico)
dc.date.accessioned2018-12-11T16:59:53Z
dc.date.available2018-12-11T16:59:53Z
dc.date.issued2016-02-01
dc.description.abstractPhysicochemical characteristics of a biomaterial directly influence its biological behavior and fate. However, anatomical and physiological particularities of the recipient site also seem to contribute with this process. The present study aimed to evaluate bone healing of maxillary sinus augmentation using a novel bioactive glass ceramic in comparison with a bovine hydroxyapatite. Bilateral sinus augmentation was performed in adult male rabbits, divided into 4 groups according to the biomaterial used: BO—particulate bovine HA Bio-Oss® (BO), BO+G—particulate bovine HA + particulate autogenous bone graft (G), BS—particulate glass ceramic (180–212 μm) Biosilicate® (BS), and BS+G—particulate glass ceramic + G. After 45 and 90 days, animals were euthanized and the specimens prepared to be analyzed under light and polarized microscopy, immunohistochemistry, scanning electron microscopy (SEM), and micro-computed tomography (μCT). Results revealed different degradation pattern between both biomaterials, despite the association with bone graft. BS caused a more intense chronic inflammation with foreign body reaction, which led to a difficulty in bone formation. Besides this evidence, SEM and μCT confirmed direct contact between newly formed bone and biomaterial, along with osteopontin and osteocalcin immunolabeling. Bone matrix mineralization was late in BS group but became similar to BO at day 90. These results clearly indicate that further studies about Biosilicate® are necessary to identify the factors that resulted in an unfavorable healing response when used in maxillary sinus augmentation.en
dc.description.affiliationDepartment of Dentistry Endodontics and Dental Materials Bauru School of Dentistry University of São Paulo – FOB/USP, Al. Octávio Pinheiro Brisola, 9-75
dc.description.affiliationOral Biology Master’s Program Sagrado Coração University – USC, Rua Irmã Arminda 10-50
dc.description.affiliationOral Biology Doctoral’s Program Bauru School of Dentistry University of São Paulo – FOB/USP, Al. Octávio Pinheiro Brisola, 9-75
dc.description.affiliationDepartment of Bioscience Federal University of Sao Paulo, Campus Baixada Santista – UNIFESP, Avenida Ana Costa, 95
dc.description.affiliationDepartment of Basic Sciences Araçatuba School of Dentistry São Paulo State University FOA/UNESP, Rua José Bonifácio 1193
dc.description.affiliationOral Biology Doctoral’s Program Sagrado Coração University USC
dc.description.affiliationCNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico)
dc.description.affiliationUnespDepartment of Basic Sciences Araçatuba School of Dentistry São Paulo State University FOA/UNESP, Rua José Bonifácio 1193
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2008/11485-8; 2009
dc.format.extent1-10
dc.identifierhttp://dx.doi.org/10.1007/s10856-015-5652-7
dc.identifier.citationJournal of Materials Science: Materials in Medicine, v. 27, n. 2, p. 1-10, 2016.
dc.identifier.doi10.1007/s10856-015-5652-7
dc.identifier.file2-s2.0-84951871830.pdf
dc.identifier.issn1573-4838
dc.identifier.issn0957-4530
dc.identifier.lattes8621510886887389
dc.identifier.scopus2-s2.0-84951871830
dc.identifier.urihttp://hdl.handle.net/11449/172357
dc.language.isoeng
dc.relation.ispartofJournal of Materials Science: Materials in Medicine
dc.relation.ispartofsjr0,647
dc.relation.ispartofsjr0,647
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleExperimental maxillary sinus augmentation using a highly bioactive glass ceramicen
dc.typeArtigo
unesp.author.lattes8621510886887389

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