Effect of furosemide treatment on the central and peripheral pressor responses to cholinergic and adrenergic agonists, angiotensin II, hypertonic solution and vasopressin

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dc.contributor.authorColombari, Débora Simões de Almeida [UNESP]
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.authorSaad, Wilson Abrão [UNESP]
dc.contributor.authorCamargo, Luiz Antonio de Arruda [UNESP]
dc.contributor.authorRenzi, Antonio [UNESP]
dc.contributor.authorLuca Junior, Laurival Antonio de [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:17:28Z
dc.date.available2014-05-27T11:17:28Z
dc.date.issued1992-08-31
dc.description.abstractThe present study was performed to investigate the effect of treatment with furosemide on the pressor response induced by intracerebroventricular (i.c.v.) injections of cholinergic (carbachol) and adrenergic (norepinephrine) agonists, angiotensin II (ANGII) and hypertonic saline (HS, 2 M NaCl). The changes induced by furosemide treatment on the pressor response to intravenous (i.v.) norepinephrine, ANGII and arginine vasopressin (AVP) were also studied. Rats with a stainless-steel cannula implanted into the lateral ventricle (LV) were used. Two injections of furosemide (30 mg/kg b.wt. each) were performed 12 and 1 h before the experiments. Treatment with furosemide reduced the pressor response induced by carbachol, norepinephrine and ANGII i.c.v., but no change was observed in the pressor response to i.c.v. 2 M NaCl. The pressor response to i.v. ANGII and norepinephrine, but not AVP, was also reduced after treatment with furosemide. These results show that the treatment with furosemide impairs the pressor responses induced by central or peripheral administration of adrenergic agonist or ANGII, as well as those induced by central cholinergic activation. The results suggest that the treatment with furosemide impairs central and peripheral pressor responses mediated by sympathetic activation and ANGII, but not those produced by AVP. © 1992.en
dc.description.affiliationDepartment of Physiology School of Dentistry Paulista State University, Araraquara
dc.description.affiliationUnespDepartment of Physiology School of Dentistry Paulista State University, Araraquara
dc.format.extent255-258
dc.identifierhttp://dx.doi.org/10.1016/0304-3940(92)90277-E
dc.identifier.citationNeuroscience Letters, v. 143, n. 1-2, p. 255-258, 1992.
dc.identifier.doi10.1016/0304-3940(92)90277-E
dc.identifier.issn0304-3940
dc.identifier.lattes4544450092427426
dc.identifier.lattes6551236936295697
dc.identifier.lattes1023597870118105
dc.identifier.lattes339253755971890
dc.identifier.lattes339253755971890
dc.identifier.scopus2-s2.0-0026714506
dc.identifier.urihttp://hdl.handle.net/11449/130473
dc.identifier.wosWOS:A1992JP03000059
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.relation.ispartofjcr2.159
dc.relation.ispartofsjr0,946
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAdrenergic drug
dc.subjectAngiotensin II
dc.subjectDiuretic
dc.subjectFurosemide
dc.subjectHypertension
dc.subjectVasopressin
dc.subjectAngiotensin
dc.subjectArgipressin
dc.subjectCarbachol
dc.subjectFurosemide
dc.subjectNoradrenalin
dc.subjectAnimal experiment
dc.subjectBlood pressure
dc.subjectCatecholaminergic system
dc.subjectCholinergic system
dc.subjectControlled study
dc.subjectDrug sensitivity
dc.subjectIntracerebroventricular drug administration
dc.subjectIntramuscular drug administration
dc.subjectIntravenous drug administration
dc.subjectMale
dc.subjectNonhuman
dc.subjectPriority journal
dc.subjectRat
dc.subjectAnimal
dc.subjectArgipressin
dc.subjectBlood Pressure
dc.subjectCarbachol
dc.subjectInjections, Intravenous
dc.subjectInjections, Intraventricular
dc.subjectMale
dc.subjectNorepinephrine
dc.subjectRats
dc.subjectSaline Solution, Hypertonic
dc.subjectSupport, Non-U.S. Gov't
dc.subjectVasoconstriction
dc.titleEffect of furosemide treatment on the central and peripheral pressor responses to cholinergic and adrenergic agonists, angiotensin II, hypertonic solution and vasopressinen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes4544450092427426[2]
unesp.author.lattes6551236936295697
unesp.author.lattes1023597870118105
unesp.author.lattes339253755971890
unesp.author.lattes339253755971890
unesp.author.orcid0000-0001-8270-2652[6]
unesp.author.orcid0000-0002-1395-4036[2]
unesp.author.orcid0000-0003-1167-4441[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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