Estimation of spontaneous blinking main sequence in normal subjects and patients with Graves' upper eyelid retraction

Página do item simplificado
dc.contributor.authorGarcia, Denny M.
dc.contributor.authorBarbosa, José Carlos [UNESP]
dc.contributor.authorPinto, Carolina T.
dc.contributor.authorCruz, Antonio Augusto V.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:20Z
dc.date.available2014-05-27T11:28:20Z
dc.date.issued2013-02-01
dc.description.abstractPurpose. We quantified the main sequence of spontaneous blinks in normal subjects and Graves' disease patients with upper eyelid retraction using a nonlinear and two linear models, and examined the variability of the main sequence estimated with standard linear regression for 10-minute periods of time. Methods. A total of 20 normal subjects and 12 patients had their spontaneous blinking measured with the magnetic search coil technique when watching a video during one hour. The main sequence was estimated with a power-law function, and with standard and trough the origin linear regressions. Repeated measurements ANOVA was used to test the mean sequence stability of 10-minute bins measured with standard linear regression. Results. In 95% of the sample the correlation coefficients of the main sequence ranged from 0.60 to 0.94. Homoscedasticity of the peak velocity was not verified in 20% of the subjects and 25% of the patients. The power-law function provided the best main sequence fitting for subjects and patients. The mean sequence of 10-minute bins measured with standard linear regression did not differ from the one-hour period value. For the entire period of observation and the slope obtained by standard linear regression, the main sequence of the patients was reduced significantly compared to the normal subjects. Conclusions. Standard linear regression is a valid and stable approximation for estimating the main sequence of spontaneous blinking. However, the basic assumptions of the linear regression model should be examined on an individual basis. The maximum velocity of large blinks is slower in Graves' disease patients than in normal subjects. © 2013 The Association for Research in Vision and Ophthalmology, Inc.en
dc.description.affiliationDepartment of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery School of Medicine of Ribeirão Preto University of São Paulo, São Paulo
dc.description.affiliationDepartment of Exact Sciences, UNESP Universidade Estadual Paulista, São Paulo
dc.description.affiliationUnespDepartment of Exact Sciences, UNESP Universidade Estadual Paulista, São Paulo
dc.format.extent1434-1442
dc.identifierhttp://dx.doi.org/10.1167/iovs.12-11452
dc.identifier.citationInvestigative Ophthalmology and Visual Science, v. 54, n. 2, p. 1434-1442, 2013.
dc.identifier.doi10.1167/iovs.12-11452
dc.identifier.issn0146-0404
dc.identifier.issn1552-5783
dc.identifier.scopus2-s2.0-84874998625
dc.identifier.urihttp://hdl.handle.net/11449/74525
dc.identifier.wosWOS:000315670300067
dc.language.isoeng
dc.relation.ispartofInvestigative Ophthalmology and Visual Science
dc.relation.ispartofjcr3.388
dc.relation.ispartofsjr2,058
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectadult
dc.subjectblinking
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectendocrine ophthalmopathy
dc.subjecteyelid retraction
dc.subjectfemale
dc.subjecthuman
dc.subjectlinear regression analysis
dc.subjectmagnetic field
dc.subjectmale
dc.subjectmathematical model
dc.subjectnonlinear regression analysis
dc.subjectpriority journal
dc.subjectupper eyelid
dc.subjectvelocity
dc.subjectAdult
dc.subjectAnalysis of Variance
dc.subjectBlinking
dc.subjectEyelids
dc.subjectFemale
dc.subjectGraves Ophthalmopathy
dc.subjectHumans
dc.subjectMale
dc.subjectVideo Recording
dc.titleEstimation of spontaneous blinking main sequence in normal subjects and patients with Graves' upper eyelid retractionen
dc.typeArtigo
dcterms.licensehttp://www.iovs.org/site/misc/terms.xhtml
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

Arquivos

Coleções

Artigos - Ciências Exatas - FCAV