Intraoperative bleeding during vitrectomy for diabetic tractional retinal detachment with versus without preoperative intravitreal bevacizumab (IBeTra study)

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dc.contributor.authorLucena, D. da R.
dc.contributor.authorRibeiro, J. A. S.
dc.contributor.authorCosta, R. A.
dc.contributor.authorBarbosa, J. C. [UNESP]
dc.contributor.authorScott, I. U.
dc.contributor.authorde Figueiredo-Pontes, L. L.
dc.contributor.authorJorge, R.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHosp Olhos Araraquara
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionPenn State Coll Med
dc.date.accessioned2014-05-20T15:31:27Z
dc.date.available2014-05-20T15:31:27Z
dc.date.issued2009-05-01
dc.description.abstractAims: To compare the amount of intraoperative intraocular bleeding in patients with diabetes with macula-involving tractional retinal detachment (TRD) undergoing pars plana vitrectomy (PPV) with and without preoperative intravitreal bevacizumab (IVB) injection.Methods: An institutional study was carried out with consecutive patients with diabetic retinopathy and macula-involving TRD of recent (3 months) onset who were randomly assigned to PPV only (PPV group) or PPV combined with one IVB (1.5 mg/0.06 ml) injection 2 weeks prior to surgery (bevacizumab (BEV)/PPV group). All patients underwent 23-gauge PPV 3 weeks after baseline. The main outcome measure was erythrocyte count in the fluid retrieved from the vitrectomy cassette using a Neubauer counting chamber.Results: The study included 20 patients. The mean erythrocyte count was 14865x10(3) (SD 19332x10(3); median 4500x10(3)) cells in the BEV/PPV group, and 176240x10(3) (SD 108375x10(3); median 166600x10(3)) cells in the PPV group. The mean erythrocyte count was significantly lower in the BEV/PPV group than in the PPV group (p < 0.0001). No major adverse events were identified.Conclusion: Preoperative IVB injection was associated with reduced intraocular bleeding during 23-gauge PPV for diabetic macula-involving TRD. Further studies are needed to confirm our preliminary findings.en
dc.description.affiliationUniv São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationHosp Olhos Araraquara, Maclma Macular Imaging & Treatment Div, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Exact Sci, São Paulo, Brazil
dc.description.affiliationPenn State Coll Med, Dept Ophthalmol, Hershey, PA USA
dc.description.affiliationPenn State Coll Med, Dept Publ Hlth Sci, Hershey, PA USA
dc.description.affiliationUniv São Paulo, Hematol Lab, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Exact Sci, São Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 302940/2005-7
dc.format.extent688-691
dc.identifierhttp://dx.doi.org/10.1136/bjo.2008.151233
dc.identifier.citationBritish Journal of Ophthalmology. London: B M J Publishing Group, v. 93, n. 5, p. 688-691, 2009.
dc.identifier.doi10.1136/bjo.2008.151233
dc.identifier.issn0007-1161
dc.identifier.urihttp://hdl.handle.net/11449/40579
dc.identifier.wosWOS:000265530100029
dc.language.isoeng
dc.publisherB M J Publishing Group
dc.relation.ispartofBritish Journal of Ophthalmology
dc.relation.ispartofjcr3.384
dc.relation.ispartofsjr2,173
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleIntraoperative bleeding during vitrectomy for diabetic tractional retinal detachment with versus without preoperative intravitreal bevacizumab (IBeTra study)en
dc.typeArtigo
dcterms.licensehttp://www.bmj.com/about-bmj/resources-authors
dcterms.rightsHolderB M J Publishing Group
unesp.author.orcid0000-0002-0800-2233[3]
unesp.author.orcid0000-0001-5995-9193[2]
unesp.author.orcid0000-0002-2652-0720[7]

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