Bupropion treatment increases epididymal contractility and impairs sperm quality with no effects on the epididymal sperm transit time of male rats

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dc.contributor.authorCavariani, Marilia Martins [UNESP]
dc.contributor.authorde Almeida Kiguti, Luiz Ricardo [UNESP]
dc.contributor.authorde Lima Rosa, Josiane [UNESP]
dc.contributor.authorde Araújo Leite, Gabriel Adan [UNESP]
dc.contributor.authorSilva, Patrícia Villela E [UNESP]
dc.contributor.authorPupo, André Sampaio [UNESP]
dc.contributor.authorDe Grava Kempinas, Wilma [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:32:58Z
dc.date.available2015-12-07T15:32:58Z
dc.date.issued2015
dc.description.abstractBupropion is a dopamine (DA) and norepinephrine (NE) reuptake inhibitor used as smoking cessation and antidepressant drug with a lower incidence of male sexual dysfunction. We showed previously that sibutramine, a norepinephrine/serotonine reuptake inhibitor, reduced male rat fertility. As there are no studies evaluating the impact of bupropion treatment on spermatic parameters and male fertility, we evaluated the effects of bupropion treatment (15 and 30 mg kg(-1), 30 days) on sexual behavior, spermatic parameters and fertility of male Wistar rats and on the epididymal duct in vitro contractility. Bupropion 15 mg kg(-1) increased the serum luteinizing hormone level and the epididymal duct contractility, but the sperm quality was not affected. At 30 mg kg(-1) bupropion impaired sperm quality increasing the incidence of non-progressive sperm. The male sexual behavior and fertility were not modified at both bupropion doses. These results, in rats, suggest the importance of studies evaluating the effects of bupropion on the human male sperm quality.en
dc.description.affiliationDepartment of Morphology, Institute of Biosciences, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.description.affiliationDepartment of Pharmacology, Institute of Biosciences, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.description.affiliationUnespDepartment of Morphology, Institute of Biosciences, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.description.affiliationUnespDepartment of Pharmacology, Institute of Biosciences, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.format.extent1007-1016
dc.identifierhttp://dx.doi.org/10.1002/jat.3089
dc.identifier.citationJournal Of Applied Toxicology : Jat, v. 35, n. 9, p. 1007-1016, 2015.
dc.identifier.doi10.1002/jat.3089
dc.identifier.issn1099-1263
dc.identifier.lattes2224433126054725
dc.identifier.lattes6326450271169741
dc.identifier.pubmed25645087
dc.identifier.urihttp://hdl.handle.net/11449/131242
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Applied Toxicology : Jat
dc.relation.ispartofsjr0,958
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectBupropionen
dc.subjectEpididymal contractionen
dc.subjectNorepinephrine transporteren
dc.subjectSperm qualityen
dc.subjectSperm transit timeen
dc.titleBupropion treatment increases epididymal contractility and impairs sperm quality with no effects on the epididymal sperm transit time of male ratsen
dc.typeArtigo
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes2224433126054725[6]
unesp.author.lattes6326450271169741
unesp.author.orcid0000-0001-6627-3448[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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